N-[(4-acetamidophenyl)methylideneamino]-2-nitrobenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(4-acetamidophenyl)methylideneamino]-2-nitrobenzamide
• 化学式: C16H14N4O4
• 分子量: 326.31
• InChiKey: YCTWXZKWDJWWAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• COMPOUNDS WITH ANTIMICROBIAL ACTIVITY
  申请人：The Hong Kong Polytechnic University

  公开号：US20200347010A1

  公开（公告）日：2020-11-05

  This invention relates to compounds of formula 1, 2 or 3 a pharmaceutically acceptable salt, or solvate thereof, wherein X 1 , Y, R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein. The compounds are antimicrobial agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds and to methods of treating bacterial and protozoal infections by administering the compounds of formula 1, 2 or 3.