N-(2-amino-1H-benzo[d]imidazol-5-yl)naphthalene-2-sulfonamide hydrochloride | 1215353-23-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(2-amino-1H-benzo[d]imidazol-5-yl)naphthalene-2-sulfonamide hydrochloride
• 英文别名: N-(2-amino-3H-benzimidazol-5-yl)naphthalene-2-sulfonamide;hydrochloride
• CAS: 1215353-23-3
• 化学式: C₁₇H₁₄N₄O₂S*ClH
• 分子量: 374.851
• InChiKey: GUUSDBOHJLUAEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.52
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基-6-硝基苯并咪唑 、 2-萘磺酰氯 在 二碳酸二叔丁酯 、 10% palladium on carbon 、 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 N-(2-amino-1H-benzo[d]imidazol-5-yl)naphthalene-2-sulfonamide hydrochloride
  参考文献：
  名称：

  The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

  摘要：

  Multidrug-resistant bacterial infections continue to be a rising global health concern. Herein is described the development of a class of novel 2-aminobenzimidazoles with antibiotic activity. These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2009.12.003

文献信息

• The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii
  作者：Robert W. Huigens、Samuel Reyes、Catherine S. Reed、Cynthia Bunders、Steven A. Rogers、Andrew T. Steinhauer、Christian Melander

  DOI：10.1016/j.bmc.2009.12.003

  日期：2010.1

  Multidrug-resistant bacterial infections continue to be a rising global health concern. Herein is described the development of a class of novel 2-aminobenzimidazoles with antibiotic activity. These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains. (C) 2009 Published by Elsevier Ltd.