2-[5-(2-Chlorophenyl)-2-furyl]-6-mercapto-4-oxo-1-phenyl-1,2,3,4-tetrahydro-5-pyrimidinecarbonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[5-(2-Chlorophenyl)-2-furyl]-6-mercapto-4-oxo-1-phenyl-1,2,3,4-tetrahydro-5-pyrimidinecarbonitrile
• 英文别名: 2-[5-(2-chlorophenyl)furan-2-yl]-6-oxo-3-phenyl-4-sulfanyl-1,2-dihydropyrimidine-5-carbonitrile
• 化学式: C₂₁H₁₄ClN₃O₂S
• 分子量: 407.9
• InChiKey: DFCXUASQWBOJMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  70.3
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] COMPOSITION FOR PREVENTION AND TREATMENT OF CANCER CONTAINING PYRIMIDINE DERIVATIVES INHIBITING ACTIVITY OF PROTEIN PHOSPHATASES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS AN ACTIVE INGREDIENT<br/>[FR] COMPOSITION DE PRÉVENTION ET DE TRAITEMENT DU CANCER CONTENANT DES DÉRIVÉS PYRIMIDINE INHIBANT L'ACTIVITÉ DE PROTÉINES PHOSPHATASES OU DES SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CEUX-CI SERVANT DE PRINCIPE ACTIF
  申请人：KOREA RES INST OF BIOSCIENCE

  公开号：WO2009078588A2

  公开（公告）日：2009-06-25

  The present invention relates to a composition for the prevention and treatment of various cancers, which inhibits protein phosphatases, containing a pyrimidine derivative as an active ingredient. The pyrimidine derivatives according to the present invention effectively inhibit the activities of protein phosphatases, such as Cdc25A and Cdc25B, and may be useful in the prevention and treatment of breast cancer, rectal cancer, non-Hodgkin's lymphoma, prostate cancer, pancreatic ductal adenocarcinoma, lung cancer, bone marrow cancer, and the like.