(+)-CM-TPMF | 477865-59-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并嘧啶类
• 英文名称: (+)-CM-TPMF
• 英文别名: N-(7-(1-(4-chloro-2-methylphenoxy)ethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-N'-methoxy-formamidine；(E)-N-{7-[1-(4-chloro-2-methylphenoxy)ethyl]-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}-N'-methoxymethanimidamide；N'-[7-[1-(4-chloro-2-methylphenoxy)ethyl]-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]-N-methoxymethanimidamide
• CAS: 477865-59-1
• 化学式: C₁₆H₁₇ClN₆O₂
• 分子量: 360.803
• InChiKey: OZWWQEQUDKBSCF-UHFFFAOYSA-N

物化性质

• 密度：
  1.39±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  85.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Selective activators of the intermediate conductance CA2+activated K+ channel KCa3.1 and their methods of use
  申请人：The Regents of the University of California

  公开号：US11173146B2

  公开（公告）日：2021-11-16

  Benzoxazole and indole type KCa3.1 activators as well as the therapeutic uses of such compounds in human or animal subjects and their use in ex vivo preservation of organs or tissues.

  苯并噁唑和吲哚类 KCa3.1 激活剂，以及此类化合物在人类或动物身上的治疗用途及其在器官或组织体外保存中的用途。
• SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
  申请人：Sørensen Ulrik Svane

  公开号：US20120101112A1

  公开（公告）日：2012-04-26

  This invention relates to novel substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as modulators of potassium channels. In other aspects the invention relates to the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
• SELECTIVE ACTIVATORS OF THE INTERMEDIATE CONDUCTANCE CA2+ACTIVATED K+ CHANNEL KCa3.1 AND THEIR METHODS OF USE
  申请人：The Regents of the University of California

  公开号：US20170056376A1

  公开（公告）日：2017-03-02

  Benzoxazole and indole type KCa3.1 activators as well as the therapeutic uses of such compounds in human or animal subjects and their use in ex vivo preservation of organs or tissues.
• [EN] SELECTIVE ACTIVATORS OF THE INTERMEDIATE CONDUCTANCE CA2+-ACTIVATED K+ CHANNEL KCA3.1 AND THEIR METHODS OF USE<br/>[FR] ACTIVATEURS SÉLECTIFS DES CANAUX K+ (KCA3.1) ACTIVÉS PAR LE CA2+ À CONDUCTANCE INTERMÉDIAIRE, ET LEURS MÉTHODES D'UTILISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2015164816A2

  公开（公告）日：2015-10-29

  Benzoxazole and indole type KCa3.1 activators as well as the therapeutic uses of such compounds in human or animal subjects and their use in ex vivo preservation of organs or tissues.