2-((diethylamino)methyl)benzene-1,4-diol | 2610-38-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-((diethylamino)methyl)benzene-1,4-diol
• 英文别名: 2-Diaethylaminomethyl-hydrochinon；2-[(Diethylamino)methyl]benzene-1,4-diol；2-(diethylaminomethyl)benzene-1,4-diol
• CAS: 2610-38-0
• 化学式: C₁₁H₁₇NO₂
• 分子量: 195.261
• InChiKey: FNDXNYZTCWDDGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-((diethylamino)methyl)benzene-1,4-diol 在 哌啶 作用下， 以 乙醇 、 丙酮 为溶剂， 生成 2,4-diamino-7-hydroxy-5H-chromeno[2,3-b]pyridine-3-carbonitrile
  参考文献：
  名称：

  Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

  摘要：

  A class of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) was discovered. These compounds have demonstrated activity against the enzyme with IC50 values as low as 130 nM and suppress the expression of TNFα in U937 cells. These represent the first small molecule inhibitors of MK-2 to be reported. © 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.01.067
• 作为产物：
  描述：

  聚合甲醛 、 二乙胺 、 对苯二酚 生成 2-((diethylamino)methyl)benzene-1,4-diol
  参考文献：
  名称：

  Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

  摘要：

  A class of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) was discovered. These compounds have demonstrated activity against the enzyme with IC50 values as low as 130 nM and suppress the expression of TNFα in U937 cells. These represent the first small molecule inhibitors of MK-2 to be reported. © 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.01.067

文献信息

• [EN] SYNTHESIS OF NOVEL IONIC LIQUIDS FROM LIGNIN-DERIVED COMPOUNDS<br/>[FR] SYNTHÈSE DE NOUVEAUX LIQUIDES IONIQUES À PARTIR DE COMPOSÉS ISSUS DE LA LIGNINE
  申请人：SANDIA CORP

  公开号：WO2014172042A1

  公开（公告）日：2014-10-23

  Methods and compositions are provided for synthesizing ionic liquids from lignin derived compounds comprising: contacting a starting material comprising lignin with a depolymerization agent to depolymerize the lignin and form a mixture of aldehyde containing compounds; contacting the mixture of aldehyde containing compounds with an amine under conditions suitable to convert the mixture of aldehyde containing compounds to a mixture of amine containing compounds; and contacting the mixture of amine containing compounds with an acid under conditions suitable to form an ammonium salt, thereby preparing the ionic liquid.

  本发明提供了一种从木质素衍生物合成离子液体的方法和组合物，包括：将含有木质素的起始材料与解聚剂接触以解聚木质素并形成含有醛化合物的混合物；将含有醛化合物的混合物与胺接触，在适宜的条件下将含有醛化合物的混合物转化为含有胺化合物的混合物；将含有胺化合物的混合物与酸接触，在适宜的条件下形成铵盐，从而制备离子液体。
• SYNTHESIS OF NOVEL IONIC LIQUIDS FROM LIGNIN-DERIVED COMPOUNDS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20160031843A1

  公开（公告）日：2016-02-04

  Methods and compositions are provided for synthesizing ionic liquids from lignin derived compounds comprising: contacting a starting material comprising lignin with a depolymerization agent to depolymerize the lignin and form a mixture of aldehyde containing compounds; contacting the mixture of aldehyde containing compounds with an amine under conditions suitable to convert the mixture of aldehyde containing compounds to a mixture of amine containing compounds; and contacting the mixture of amine containing compounds with an acid under conditions suitable to form an ammonium salt, thereby preparing the ionic liquid.

  提供了一种从木质素衍生化合物合成离子液体的方法和组合物，包括：将含有木质素的起始材料与解聚剂接触，以解聚木质素并形成含有醛基化合物的混合物；将含有醛基化合物的混合物与胺在适宜的条件下接触，以转化为含有胺基化合物的混合物；将含有胺基化合物的混合物与酸在适宜的条件下接触，以形成铵盐，从而制备离子液体。
• Synthesis of novel ionic liquids from lignin-derived compounds
  申请人：THE REGENTS OF THE UNVIERSITY OF CALIFORNIA

  公开号：US10155735B2

  公开（公告）日：2018-12-18

  Methods and compositions are provided for synthesizing ionic liquids from lignin. Methods and compositions are also provided for treating lignin with ionic liquids.

  提供了从木质素合成离子液体的方法和组合物。还提供了用离子液体处理木质素的方法和组合物。
• US9765044B2
  申请人：——

  公开号：US9765044B2

  公开（公告）日：2017-09-19
• Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
  作者：David R. Anderson、Shridhar Hegde、Emily Reinhard、Leslie Gomez、William F. Vernier、Len Lee、Shuang Liu、Aruna Sambandam、Patricia A. Snider、Liaqat Masih

  DOI：10.1016/j.bmcl.2005.01.067

  日期：2005.3

  A class of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) was discovered. These compounds have demonstrated activity against the enzyme with IC50 values as low as 130 nM and suppress the expression of TNFα in U937 cells. These represent the first small molecule inhibitors of MK-2 to be reported. © 2005 Elsevier Ltd. All rights reserved.