3,5-ditert-butyl-4-hydroxy-N-(1,3-thiazol-2-yl)benzamide | 57844-06-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-ditert-butyl-4-hydroxy-N-(1,3-thiazol-2-yl)benzamide
• CAS: 57844-06-1
• 化学式: C₁₈H₂₄N₂O₂S
• 分子量: 332.5
• InChiKey: FQWVVMGMCGXFKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  90.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
  申请人：——

  公开号：US20040214827A1

  公开（公告）日：2004-10-28

  The present invention provides novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups and the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species and/or excess Zn ions, in particular stroke, Parkinson's disease, Alzheimer's disease. The compounds of the invention have not only low toxicity but also similar or superior LPO inhibition activity to references. They also effectively inhibit the cerebral neuronal cell death by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.
• US7229988B2
  申请人：——

  公开号：US7229988B2

  公开（公告）日：2007-06-12
• US7511034B2
  申请人：——

  公开号：US7511034B2

  公开（公告）日：2009-03-31