(1S,2S,6R,7R)-4-(4-fluoro-3-nitrophenyl)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (1S,2S,6R,7R)-4-(4-fluoro-3-nitrophenyl)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
• 化学式: C15H11FN2O4
• 分子量: 302.26
• InChiKey: BRQWJRXWXQPCLC-GRUGVGOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  83.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] ANTAGONISTS OF THE THYROID-STIMULATING HORMONE RECEPTOR (TSHR)<br/>[FR] ANTAGONISTES DU RÉCEPTEUR DE LA THYRÉOSTIMULINE (TSHR)
  申请人：FORSCHUNGSVERBUND BERLIN EV

  公开号：WO2017186793A1

  公开（公告）日：2017-11-02

  The invention relates to chemical compounds that are useful in the treatment of a subject afflicted by a thyroid disease, in particular to compounds that exhibit activity as thyroid-stimulating hormone receptor (TSHR) antagonists and their use in the treatment of hyperthyroidism, Graves' disease, Graves' Ophthalmopathy and thyroid cancer.

  该发明涉及对患有甲状腺疾病的受试者有用的化合物，特别是表现为甲状腺刺激激素受体（TSHR）拮抗剂活性的化合物以及它们在治疗甲状腺功能亢进症、Graves病、Graves眼病和甲状腺癌中的应用。
• Antagonists of the thyroid-stimulating hormone receptor (TSHR)
  申请人：Forschungsverbund Berlin e.V.

  公开号：US10596168B2

  公开（公告）日：2020-03-24

  Chemical compounds are useful in the treatment of a subject afflicted by a thyroid disease. The compounds exhibit activity as thyroid-stimulating hormone receptor (TSHR) antagonists and can be used in the treatment of hyperthyroidism, Graves' disease, Graves' Ophthalmopathy and thyroid cancer.

  化合物可用于治疗甲状腺疾病患者。这些化合物具有促甲状腺激素受体（TSHR）拮抗剂的活性，可用于治疗甲状腺机能亢进症、巴塞杜氏病、巴塞杜氏眼病和甲状腺癌。
• ANTAGONISTS OF THE THYROID-STIMULATING HORMONE RECEPTOR (TSHR)
  申请人：Forschungsverbund Berlin e.V.

  公开号：US20190134024A1

  公开（公告）日：2019-05-09

  Chemical compounds are useful in the treatment of a subject afflicted by a thyroid disease. The compounds exhibit activity as thyroid-stimulating hormone receptor (TSHR) antagonists and can be used in the treatment of hyperthyroidism, Graves' disease, Graves' Ophthalmopathy and thyroid cancer.