2-(2,4-dichlorophenoxy)-N-(3-methylpyridin-2-yl)acetamide | 5538-97-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,4-dichlorophenoxy)-N-(3-methylpyridin-2-yl)acetamide
• CAS: 5538-97-6
• 化学式: C₁₄H₁₂Cl₂N₂O₂
• 分子量: 311.2
• InChiKey: WJGDFZCVQHCNSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• MODULATING IRES-MEDIATED TRANSLATION
  申请人：Thompson Sunnie R.

  公开号：US20120065247A1

  公开（公告）日：2012-03-15

  Provided herein are compounds and methods for use in preventing or treating a viral infection mediated by a virus comprising an IRES-containing RNA molecule or cancer related to an increase or decrease in IRES-mediated translation of an RNA molecule. Also provided are methods of inhibiting or promoting IRES-mediated translation. Also provided are methods of screening for an agent that inhibits IRES-mediated translation.
• TREATING VIRAL INFECTIONS HAVING VIRAL RNAs TRANSLATED BY A NON-IRES MEDIATED MECHANISM
  申请人：THE UAB RESEARCH FOUNDATION

  公开号：US20150105433A1

  公开（公告）日：2015-04-16

  Provided herein are methods for preventing or treating a viral infection in a subject, wherein the viral infection is mediated by a virus comprising one or more viral RNA molecules translated by a ribosomal shunting mechanism or a non-IRES mediated mechanism. The methods comprise administering to a subject an agent that reduces ribosomal protein (Rps25) expression or function. Also provided are methods of inhibiting or promoting ribosomal shunting-mediated translation or non-IRES mediated translation. Also provided are methods of screening for an agent that inhibits or promotes ribosomal shunting-mediated translation or non-IRES mediated translation.
• [EN] MODULATING IRES-MEDIATED TRANSLATION<br/>[FR] MODULATION DE LA TRADUCTION À MÉDIATION PAR LES SÉQUENCES IRES
  申请人：UAB RESEARCH FOUNDATION

  公开号：WO2010111653A2

  公开（公告）日：2010-09-30

  Provided herein are compounds and methods for use in preventing or treating a viral infection mediated by a virus comprising an IRES-containing RNA molecule or cancer related to an increase or decrease in IRES-mediated translation of an RNA molecule. Also provided are methods of inhibiting or promoting IRES-mediated translation. Also provided are methods of screening for an agent that inhibits IRES-mediated translation.