1-[2-(Phenylsulfonyl)ethyl]piperazine | 866717-48-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[2-(Phenylsulfonyl)ethyl]piperazine
• 英文别名: 1-[2-(benzenesulfonyl)ethyl]piperazine
• CAS: 866717-48-8
• 化学式: C₁₂H₁₈N₂O₂S
• mdl: MFCD03790948
• 分子量: 254.35
• InChiKey: TWLDIXBOMAAMPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS<br/>[FR] COMPOSÉS SUBSTITUÉS DE PYRAZOLO[1,5-A]PYRIDINES COMME INHIBITEURS DE LA KINASE RET
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2017011776A1

  公开（公告）日：2017-01-19

  Provided herein are compounds of the General Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.

  本文提供了一般式I的化合物及其立体异构体和药用可接受的盐或溶剂，其中A、B、D、E、X1、X2、X3和X4的含义如规范中所述，这些化合物是RET激酶的抑制剂，可用于治疗和预防可以用RET激酶抑制剂治疗的疾病，包括由RET激酶介导的疾病或紊乱。
• US7273882B2
  申请人：——

  公开号：US7273882B2

  公开（公告）日：2007-09-25
• [EN] SUBSTITUTED ACETANILIDES AND BENZAMIDES FOR THE TREATMENT OF ASTHMA AND PULMONARY INFLAMMATION<br/>[FR] ACETANILIDES ET BENZAMIDES SUBSTITUES UTILISES DANS LE TRAITEMENT DE L'ASTHME ET DES INFLAMMATIONS PULMONAIRES
  申请人：CORUS PHARMA

  公开号：WO2005025498A2

  公开（公告）日：2005-03-24

  Substituted acetanilide or benzamide compositions or formulations for delivery by aerosolization are described. The formulation contains an efficacious amount of acetanilide or benzamide compound able to inhibit inflammation in asthmatic lungs. Compounds of the invention are formulated in 5 ml solution of a quarter normal saline having pH between 5.0 and 7.0. The method for treatment of respiratory tract inflammation by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 µ, produced by nebulization or dry powder inhaler.
• [EN] AMINOACETAMIDE ACYL GUANIDINES AS BETA-SECRETASE INHIBITORS<br/>[FR] GUANIDINES D'ACYLE ACETAMIDE AMINE EN TANT QU'INHIBITEURS DE BETA-SECRETASE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2007002220A2

  公开（公告）日：2007-01-04

  [EN] There is provided a series of substituted acyl guanidines of Formula (Ik) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R₂, R₃, R₄, R₅, R₂₅, R₂₆ and R₂₇ as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by ß-secretase and, more specifically, inhibit the production of Aß-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to ß-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
  [FR] La présente invention a trait à une série de guanidines d'acyle substitués de formule (Ik), dans laquelle: R₂, R₃, R₄, R₅, R₂₅, R₂₆ et R₂₇ sont tels que définis dans la description, ou un stéréoisomère; ou un sel pharmaceutiquement acceptable de celles-ci; à leurs compositions pharmaceutiques et leurs procédés d'utilisation. Ces composés sont inhibiteurs du processus de la protéine précurseur d'amyloïde par la ß-sécrétase et, plus spécifiquement, inhibiteurs de la production de peptide Aß. La présente invention a également trait à des composés utiles dans le traitement de troubles neurologiques liés à la production de ß-amyloïde, tels que la maladie d'Alzheimer et d'autres conditions affectées par l'activité anti-amyloïde.