(4-ethyl-2-phenyl-4,5-dihydro-oxazol-4-yl)-methanol | 24498-18-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-ethyl-2-phenyl-4,5-dihydro-oxazol-4-yl)-methanol
• 英文别名: (4-Aethyl-2-phenyl-4,5-dihydro-oxazol-4-yl)-methanol；(4-ethyl-2-phenyl-5H-1,3-oxazol-4-yl)methanol
• CAS: 24498-18-8
• 化学式: C₁₂H₁₅NO₂
• 分子量: 205.257
• InChiKey: UBBITZJUAPCBRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  41.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基-2-乙基-1,3-丙二醇 、 苯甲酸 在 xylene 作用下， 生成 (4-ethyl-2-phenyl-4,5-dihydro-oxazol-4-yl)-methanol
  参考文献：
  名称：

  Amino Acids. IV. Amino Acids Related to Serine

  摘要：

  DOI：

  10.1021/ja01223a011

文献信息

• METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND OR SALT THEREOF
  申请人：Onomura Osamu

  公开号：US20140012010A1

  公开（公告）日：2014-01-09

  Provided is a process for producing an optically active compound represented by Formula (3): (wherein R 1 is an alkyl group, an alkynyl group, an alkenyl group, an aliphatic heterocyclic group, a cycloalkyl group, an aryl group, an aralkyl group, or an aromatic heterocyclic group, and any hydrogen atom of R 1 may be replaced with a substituent; R 2 is a hydrogen atom or a group which is not reactive in the reaction below; and * represents a chiral center) or a salt thereof by subjecting a compound represented by Formula (1): (wherein R 1 and R 2 have the same meanings as defined in Formula (3)) to a ring closure reaction in the presence of a chiral ligand having 1 or more coordination sites, a Lewis acid represented by Formula (2): M m Z n (2) (wherein M is a metal ion, Z is a counter anion of M, and m and n are integers of 1 to 4), and a sulfonyl halide having an optionally substituted alkyl or phenyl group
• US8969585B2
  申请人：——

  公开号：US8969585B2

  公开（公告）日：2015-03-03
• Amino Acids. IV. Amino Acids Related to Serine
  作者：John H. Billman、Earl E. Parker

  DOI：10.1021/ja01223a011

  日期：1945.7