Ethyl 2-[[4-[(5-chloro-1,3-dimethylpyrazol-4-yl)methyl]-1,4-diazepane-1-carbonyl]amino]benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl 2-[[4-[(5-chloro-1,3-dimethylpyrazol-4-yl)methyl]-1,4-diazepane-1-carbonyl]amino]benzoate
• 化学式: C₂₁H₂₈ClN₅O₃
• 分子量: 433.9
• InChiKey: OWQNYSSISIULEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  79.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Homopiperazine compounds that inhibit ribosomal frameshifting by binding to rna pseudoknot structure of sars coronavirus
  申请人：Sungkyunkwan University Foundation for Corporate Collaboration

  公开号：EP1941885A2

  公开（公告）日：2008-07-09

  Provided is a homopiperazine compound for inhibiting ribosomal frameshifting by binding to an RNA pseudoknot structure of SARS coronavirus. Particularly, the present invention provides a pharmaceutical composition for inhibiting synthesis of protein induced by -1 frameshifting by binding to an RNA pseudoknot structure specifically existing in SARS coronavirus. The composition includes a therapeutically effective amount of homopiperazine compound of following chemical formula 1 or a pharmaceutically accepted salt thereof, and a pharmaceutically accepted carrier or excipient.

  本发明提供了一种通过与 SARS 冠状病毒的 RNA 假结结构结合来抑制核糖体移帧的均哌嗪化合物。特别是，本发明提供了一种药物组合物，用于通过与特异性存在于 SARS 冠状病毒中的 RNA 假结结构结合来抑制-1 换帧诱导的蛋白质合成。该组合物包括治疗有效量的下述化学式 1 的均哌嗪化合物或其药学上可接受的盐，以及药学上可接受的载体或赋形剂。
• Homopiperazine compounds that inhibit ribosomal frameshifting by binding to RNA pseudoknot structure of SARS coronavirus
  申请人：Sungkyunkwan University Foundation for Corporate Collaboration

  公开号：EP1941885B1

  公开（公告）日：2015-03-04
• HOMOPIPERAZINE COMPOUNDS THAT INHIBIT RIBOSOMAL FRAMESHIFTING BY BINDING TO RNA PSEUDOKNOT STRUCTURE OF SARS CORONAVIRUS
  申请人：PARK Hyun-Ju

  公开号：US20080207597A1

  公开（公告）日：2008-08-28

  Provided is a homopiperazine compound for inhibiting ribosomal frameshifting by binding to an RNA pseudoknot structure of SARS coronavirus. Particularly, the present invention provides a pharmaceutical composition for inhibiting synthesis of protein induced by −1 frameshifting by binding to an RNA pseudoknot structure specifically existing in SARS coronavirus. The composition includes a therapeutically effective amount of homopiperazine compound of following chemical formula 1 or a pharmaceutically accepted salt thereof, and a pharmaceutically accepted carrier or excipient.
• US7803796B2
  申请人：——

  公开号：US7803796B2

  公开（公告）日：2010-09-28