2,7-Dimethyl-phenothiazin | 55601-81-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 2,7-Dimethyl-phenothiazin
• 英文别名: 2,7-Dimethyl-10H-phenothiazine
• CAS: 55601-81-5
• 化学式: C₁₄H₁₃NS
• 分子量: 227.33
• InChiKey: QNMVXOGCFYYMNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-甲基-苯并噻唑 、 3-溴-4-碘甲苯 在 N-(benzyloxy)-1H-pyrrole-2-carboxamide 、 copper(II) acetate monohydrate 、 sodium hydroxide 作用下， 反应 12.0h， 以60%的产率得到2,7-Dimethyl-phenothiazin
  参考文献：
  名称：

  铜催化多米诺反应合成吩噻嗪

  摘要：

  探索了一种由苯并噻唑和芳基邻二卤化物一锅法合成吩噻嗪的方法。对反应机理的初步研究表明，它遵循多米诺骨牌过程，包括苯并噻唑的水解，然后是 C-S 偶联和 C-N 偶联。催化剂体系的低负载量（铜和配体均为 5 mol%）、温和的实验条件（90 °C、12 小时）以及绿色反应介质的使用使该合成对学术界和工业界非常有吸引力。

  DOI：

  10.1002/ejoc.201500667

文献信息

• 一种合成吩噻嗪类化合物的方法
  申请人：中山大学

  公开号：CN104529938B

  公开（公告）日：2016-06-08

  本发明开发了一种以苯并噻唑及其衍生物和邻碘溴苯及其衍生物为原料，以铜或者铜盐/N-烷氧基-1H-吡咯酰胺体系为铜催化剂合成吩噻嗪类化合物的方法。该方法是一条全新的合成吩噻嗪类化合物的方法。其具有温度低、反应时间短、所用溶剂低毒及底物的适应性广的特点。在药物、农药及材料的制备方面具有广阔的应用前景。
• ANTIVIRAL COMPOUNDS
  申请人：Guo Hongyan

  公开号：US20120157404A1

  公开（公告）日：2012-06-21

  The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  该发明涉及抗病毒化合物、含有这些化合物的组合物以及包括给予这些化合物的治疗方法，还涉及用于制备这些化合物的过程和中间体。
• COMPOSITION AND LUMINESCENT ELEMENT OBTAINED USING SAME
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2518111A1

  公开（公告）日：2012-10-31

  A composition comprising (1) a first crosslinkable polymer compound having an aromatic conjugated repeating unit and a crosslinkable group and having at least one of a light emitting property and charge transportability, and (2) a second crosslinkable polymer compound having an aromatic conjugated repeating unit and a crosslinkable group at least one of which is different from the aromatic conjugated repeating unit in the first crosslinkable polymer compound and the crosslinkable group in the first crosslinkable polymer compound, and having at least one of a light emitting property and charge transportability, wherein at least one of the first crosslinkable polymer compound and the second crosslinkable polymer compound has a crosslinkable group represented by the following formula (Z-3) or (Z-4): in the formulae, RC represents a hydrogen atom, or a substituent such as an unsubstituted or substituted alkyl group or the like, the plurality of RC moieties may be the same or different.

  一种组合物，包含(1)具有芳香共轭重复单元和可交联基团且具有发光特性和电荷传输性中至少一种特性的第一可交联聚合物化合物，以及(2)具有芳香共轭重复单元和可交联基团（其中至少一个不同于第一可交联聚合物化合物中的芳香共轭重复单元和第一可交联聚合物化合物中的可交联基团）且具有发光特性和电荷传输性中至少一种特性的第二可交联聚合物化合物、其中第一可交联聚合物化合物和第二可交联聚合物化合物中的至少一个具有下式（Z-3）或（Z-4）所代表的可交联基团： 式中，RC 代表氢原子或取代基，如未取代或取代的烷基等，多个 RC 基团可以相同或不同。
• Antiviral compounds
  申请人：Gilead Pharmasset LLC

  公开号：EP2857394A1

  公开（公告）日：2015-04-08

  The invention is related to anti-viral compounds of formula (Ic): E-V-Z-P-M-A-A-M-P-Z-V-E (Ic) or a pharmaceutically acceptable salt thereof, wherein: each E is methoxycarbonylamino; each V is V0; each Z is -C(=O)-; each P is each M is independently imidazolyl or benzimidazolyl; compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及式 (Ic) 的抗病毒化合物： E-V-Z-P-M-A-A-M-P-Z-V-E (Ic) 或其药学上可接受的盐，其中 每个 E 是甲氧基羰基氨基； 每个 V 是 V0； 每个 Z 是-C(=O)-； 每个 P 是 每个 M 独立地为咪唑基或苯并咪唑基； 含有此类化合物的组合物、包括施用此类化合物的治疗方法，以及制备此类化合物的工艺和中间体。
• COMPOSITION AND LIGHT EMITTING DEVICE USING THE SAME
  申请人：Hirano Keiko

  公开号：US20120306358A1

  公开（公告）日：2012-12-06

  A composition comprising (1) a first crosslinkable polymer compound having an aromatic conjugated repeating unit and a crosslinkable group and having at least one of a light emitting property and charge transportability, and (2) a second crosslinkable polymer compound having an aromatic conjugated repeating unit and a crosslinkable group at least one of which is different from the aromatic conjugated repeating unit in the first crosslinkable polymer compound and the crosslinkable group in the first crosslinkable polymer compound, and having at least one of a light emitting property and charge transportability, wherein at least one of the first crosslinkable polymer compound and the second crosslinkable polymer compound has a crosslinkable group represented by the following formula (Z-3) or (Z-4): in the formulae, R c represents a hydrogen atom, or a substituent such as an unsubstituted or substituted alkyl group or the like, the plurality of R c moieties may be the same or different.