1-(3,4-dichloro-phenyl)-3-[5-(1-phenyl-ethyl)-[1,3,4]thiadiazol-2-yl]-urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3,4-dichloro-phenyl)-3-[5-(1-phenyl-ethyl)-[1,3,4]thiadiazol-2-yl]-urea
• 英文别名: 1-(3,4-Dichlorophenyl)-3-[5-(1-phenylethyl)-1,3,4-thiadiazol-2-yl]urea
• 化学式: C₁₇H₁₄Cl₂N₄OS
• 分子量: 393.296
• InChiKey: QVFMPPPLVLDRDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  95.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Use of thiadiazoleurea derivatives
  申请人：Burgdorf Lars

  公开号：US20070191353A1

  公开（公告）日：2007-08-16

  Use of compounds of the formula (I), in which Ar 1 , Ar 2 and Z have the meanings indicated in Patent Claim 1 , for the prophylaxis and/or treatment of diseases in which the inhibition, regulation and/or modulation of signal transduction by kinases, in particular RAF kinases, plays a role.

  使用公式（I）中Ar1、Ar2和Z具有专利权要求1中所示含义的化合物，用于预防和/或治疗信号转导激酶，特别是RAF激酶的抑制、调节和/或调节在其中起作用的疾病。
• [EN] COMPOUNDS USEFUL AS MEDICAMENTS<br/>[FR] COMPOSÉS UTILES COMME MÉDICAMENTS
  申请人：BETAGENON AB

  公开号：WO2010073011A2

  公开（公告）日：2010-07-01

  There is provided a compound of formula (I), wherein the dotted lines, X, T, G, Y, A1 to A5 and D1 to D5 have meanings given in the description, which compounds are useful in the treatment of conditions or disorders ameliorated by the activation of AMPK, for example skin diseases, lung disease, obesity, dry-type age-related macular degeneration, cardioprotection or, preferably, hyperinsulinemia, diabetes, cancer, fibrosis, neurodegenerative diseases, sexual dysfunction, heart failure, inflammation and osteoporosis.