N-(2-hydroxybenzyl)-4-aminopyridine | 634594-73-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-hydroxybenzyl)-4-aminopyridine
• 英文别名: 2-[(4-pyridinylamino)methyl]Phenol；2-[(pyridin-4-ylamino)methyl]phenol
• CAS: 634594-73-3
• 化学式: C₁₂H₁₂N₂O
• 分子量: 200.24
• InChiKey: LPBPHAUAGIIPKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  45.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二(氰基苯)二氯化钯 、 N-(2-hydroxybenzyl)-4-aminopyridine 以 乙醇 为溶剂， 生成 dichloro-bis(N-(2-hydroxybenzyl)-4-aminopyridine)palladium(II)
  参考文献：
  名称：

  Cu(II) and Pd(II) complexes of N-(2-hydroxybenzyl)aminopyridines

  摘要：

  N-(2-Hydroxybenzyl)aminopyridines (L) react with Cu(II) and Pd(II) ions to form complexes in the compositions Cu(Li)2(CH3COO)(2) center dot nH(2)O (n = 0.14), Pd(L-i)(2)Cl-2 center dot nC(2)H(5)OH (n = 0, 2) and Pd(L-2)(2)Cl-2 center dot 2H(2)O- In the complexes, the ligands are neutral and monodentate which coordinate through pyridinic nitrogen. Crystal data of the complexes obtained from 2-amino pyridine derivative have pointed such a coordinating route and comparison of the spectral data suggests the validity of similar complexation modes of other analog ligands. Cu(II) complex of N-(2-hydroxybenzyl)-2-aminopyridine (L), [Cu(L-1)(2)(CH3COO)(2)] has slightly distorted square planar cis-mononuclear structure which is built by two oxygen atoms of two monodentate carboxylic groups disposed in cis-position and two nitroaen atoms of two pyridine rings. The remaining two oxygen atoms of two carboxylic groups form two Cu and H bridges containing cycles which joint at same four coordinated copper(II) ion. IR and electronic spectral data and the magnetic moments as well as the thermogravimetric analyses also specify on mononuclear octahedric structure of complexes [Cu(L-2)(2)(CH3COO)(2) center dot 2H(2)O] and [Cu(L-3)(2)(CH3COO)(2) center dot 4H(2)O] where L-2 and L-3 are N-(2-hydroxybenzyl)-2- or 3-aminopyridines, respectively. X-ray analysis for [Pd(L-1)(2)Cl-2 center dot 2C(2)H(5)OH] show square planar environment around Pd(II) ion formed by two chlorine atoms in trans position and two nitrogen atoms of pyridine rings. The spectral data indicate structural similarity in the complexes obtained via ligand exchange between PdCl2(PhCN)(2) and 3-amino and 4-aminopyridine derivatives. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2007.03.015
• 作为产物：
  描述：

  N-(2-hydroxybenzylidene)pyridin-4-amine 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成 N-(2-hydroxybenzyl)-4-aminopyridine
  参考文献：
  名称：

  A Quick Route for the Synthesis of 3-Aryl-3,4-dihydro-2H-benz[e]-1,3-oxazin-2-ones

  摘要：

  N-(2-羟基)-苄基-芳香胺（1）在20-25 ºC的DMSO中与碳酰二咪唑环化，20-30分钟后获得了3-芳基-3,4-二氢-2H-benz[e]-1,3-噁唑啉-2-酮（2），产率非常高。

  DOI：

  10.14233/ajchem.2013.14053

文献信息

• A Quick Route for the Synthesis of 3-Aryl-3,4-dihydro-2H-benz[e]-1,3-oxazin-2-ones
  作者：Davender Kumar Shukla、Manju Rani、Arif Ali Khan

  DOI：10.14233/ajchem.2013.14053

  日期：——

  N-(2-Hydroxy)-benzyl-arylamines (1) gave substantially pure 3-aryl-3,4-dihydro-2H-benz[e]-1,3-oxazin-2-one 2 on cyclization with carbonyldiimidazole in DMSO in 20-30 min at 20-25 ºC in excellent yields.

  N-(2-羟基)-苄基-芳香胺（1）在20-25 ºC的DMSO中与碳酰二咪唑环化，20-30分钟后获得了3-芳基-3,4-二氢-2H-benz[e]-1,3-噁唑啉-2-酮（2），产率非常高。
• Cu(II) and Pd(II) complexes of N-(2-hydroxybenzyl)aminopyridines
  作者：Bahattin Yalçın、Perizad A. Fatullayeva、Orhan Büyükgüngör、Başak Koşar、Sülin Taşcıoğlu、Akif I. Israfilov、Zaur D. Ibayev、Ajdar A. Medjidov、Adnan Aydın

  DOI：10.1016/j.poly.2007.03.015

  日期：2007.8

  N-(2-Hydroxybenzyl)aminopyridines (L) react with Cu(II) and Pd(II) ions to form complexes in the compositions Cu(Li)2(CH3COO)(2) center dot nH(2)O (n = 0.14), Pd(L-i)(2)Cl-2 center dot nC(2)H(5)OH (n = 0, 2) and Pd(L-2)(2)Cl-2 center dot 2H(2)O- In the complexes, the ligands are neutral and monodentate which coordinate through pyridinic nitrogen. Crystal data of the complexes obtained from 2-amino pyridine derivative have pointed such a coordinating route and comparison of the spectral data suggests the validity of similar complexation modes of other analog ligands. Cu(II) complex of N-(2-hydroxybenzyl)-2-aminopyridine (L), [Cu(L-1)(2)(CH3COO)(2)] has slightly distorted square planar cis-mononuclear structure which is built by two oxygen atoms of two monodentate carboxylic groups disposed in cis-position and two nitroaen atoms of two pyridine rings. The remaining two oxygen atoms of two carboxylic groups form two Cu and H bridges containing cycles which joint at same four coordinated copper(II) ion. IR and electronic spectral data and the magnetic moments as well as the thermogravimetric analyses also specify on mononuclear octahedric structure of complexes [Cu(L-2)(2)(CH3COO)(2) center dot 2H(2)O] and [Cu(L-3)(2)(CH3COO)(2) center dot 4H(2)O] where L-2 and L-3 are N-(2-hydroxybenzyl)-2- or 3-aminopyridines, respectively. X-ray analysis for [Pd(L-1)(2)Cl-2 center dot 2C(2)H(5)OH] show square planar environment around Pd(II) ion formed by two chlorine atoms in trans position and two nitrogen atoms of pyridine rings. The spectral data indicate structural similarity in the complexes obtained via ligand exchange between PdCl2(PhCN)(2) and 3-amino and 4-aminopyridine derivatives. (c) 2007 Elsevier Ltd. All rights reserved.