1-Adamantylpyridinium bromide | 93588-28-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-Adamantylpyridinium bromide
• 英文别名: 1-(1-adamantyl)pyridin-1-ium
• CAS: 93588-28-4
• 化学式: C15H20N+
• mdl: MFCD00168146
• 分子量: 214.33
• InChiKey: SWNCWKCFRVMYDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• Chemical address tags
  申请人：Rosania R. Gustavo

  公开号：US20070111251A1

  公开（公告）日：2007-05-17

  The present invention provides methods and compositions related to the fields of chemoinformatics, chemogenomics, drug discovery and development, and drug targeting. In particular, the present invention provides subcellular localization signals (e.g., chemical address tags) that influence (e.g., direct) subcellular and organelle level localization of associated compounds (e.g., drugs and small molecule therapeutics, radioactive species, dyes and imagining agents, proapoptotic agents, antibiotics, etc) in target cells and tissues. The compositions of the present invention modulate the pharmacological profiles of associated compounds by influencing the compound's accumulation, or exclusion, from subcellular loci such as mitochondria, endoplasmic reticulum, cytoplasm, vesicles, granules, nuclei and nucleoli and other subcellular organelles and compartments. The present invention also provides methods for identifying chemical address tags, predicting their targeting characteristics, and for rational designing chemical libraries comprising chemical address tags.

  本发明提供与化学信息学、化学基因组学、药物发现和开发以及药物靶向相关的方法和组合物。特别地，本发明提供亚细胞定位信号（例如，化学地址标签），其影响（例如，指导）相关化合物（例如，药物和小分子治疗剂、放射性物质、染料和成像剂、促凋亡剂、抗生素等）在目标细胞和组织中的亚细胞和细胞器水平定位。本发明的组分通过影响化合物在线粒体、内质网、细胞质、囊泡、颗粒、细胞核和核仁以及其他亚细胞器和区域等亚细胞位置的累积或排除，调节相关化合物的药理特性。本发明还提供了识别化学地址标签、预测其靶向特性以及合理设计包含化学地址标签的化学库的方法。
• Synthesis of MCM-58
  申请人：——

  公开号：US20020164284A1

  公开（公告）日：2002-11-07

  This invention provides a process for the synthesis of MCM-58 using 1-(1-adamantyl) pyridinium cations as a directing agent. The resultant MCM-58 is useful in a variety of hydrocarbon conversion reactions including toluene disproportionation, transalkylation of aromatics, reaction of paraffins with aromatics, paraffin isomerization and alkylation of aromatics with olefins.

  本发明提供了一种以 1-(1-金刚烷基)吡啶鎓阳离子为引导剂合成 MCM-58 的工艺。 得到的 MCM-58 可用于各种烃类转化反应，包括甲苯歧化、芳烃的反式烷基化、石蜡与芳烃的反应、石蜡异构化以及芳烃与烯烃的烷基化。
• Combinatorial fluorescent library based on the styryl scaffold
  申请人：Chang Young-Tae

  公开号：US20050054006A1

  公开（公告）日：2005-03-10

  A combinatorial library of fluorescent compounds useful as organelle-specific probes are produced by reacting an aldehyde with a 2- or 4-methylpyridinium salt.

  通过醛与 2-或 4-甲基吡啶鎓盐的反应，产生了一个可用作细胞器特异性探针的荧光化合物组合库。
• CYANOPHOSPHORUS COMPOUNDS AND THEIR PREPARATION
  申请人：MONSANTO COMPANY

  公开号：EP0948502A1

  公开（公告）日：1999-10-13
• CYANOPHOSPHONATE DERIVATIVES
  申请人：MONSANTO COMPANY

  公开号：EP0948506A1

  公开（公告）日：1999-10-13