4-[4-[6-[4-(Dibutylazaniumyl)phenyl]hexa-1,3,5-trienyl]pyridin-1-ium-1-yl]butane-1-sulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[4-[6-[4-(Dibutylazaniumyl)phenyl]hexa-1,3,5-trienyl]pyridin-1-ium-1-yl]butane-1-sulfonate
• 英文别名: 4-[4-[6-[4-(dibutylazaniumyl)phenyl]hexa-1,3,5-trienyl]pyridin-1-ium-1-yl]butane-1-sulfonate
• 化学式: C29H41N2O3S+
• 分子量: 497.7
• InChiKey: VJFBYTPFDXZYDN-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  35
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  69.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ANTIMICROBIAL SURFACE COATING FORMATION, DETECTION, QUANTIFICATION AND REACTIVATION SYSTEMS AND METHODS
  申请人：B/E Aerospace, Inc.

  公开号：EP3936858A1

  公开（公告）日：2022-01-12

  Disclosed are methods (100) for detecting an antimicrobial surface coating on a substrate (300) including the steps of applying (106) an anionic agent to a surface of the substrate (300), allowing (108) the anionic agent to bond to antimicrobial surface coating present on the substrate (300), removing (110) unbonded anionic agent, subjecting (112) the surface of the substrate (300) to a predetermined process to effect a change in the bonded anionic agent, observing (114) the change, and verifying (116), based on the observed change, the presence of antimicrobial surface coating on the substrate (300). The anionic agent may be an anionic thermochromic dye showing a visually detectable color change upon application of heat, or an anionic voltage-sensitive dye showing a change in spectral property upon application of a voltage, or an anionic fluorophoric dye showing fluorescence upon irradiation with UV light. Further disclosed are antimicrobial surface coating solutions, methods for their application, and methods for reactivated antimicrobial surface coatings.

  本发明公开了用于检测基底（300）上抗微生物表面涂层的方法（100），包括以下步骤：在基底（300）的表面涂抹（106）阴离子剂，使（108）阴离子剂与存在于基底（300）上的抗微生物表面涂层结合、去除 (110) 未粘合的阴离子剂，将基质 (300) 的表面置于预先确定的过程 (112) 中，使粘合的阴离子剂发生变化，观察 (114) 变化，并根据观察到的变化验证 (116) 基质 (300) 上是否存在抗微生物表面涂层。阴离子剂可以是阴离子热致变色染料，在加热时显示可目测的颜色变化；或者是阴离子压敏染料，在施加电压时显示光谱特性的变化；或者是阴离子荧光染料，在紫外线照射时显示荧光。进一步公开的还有抗菌表面涂层溶液、其应用方法以及重新激活抗菌表面涂层的方法。
• Methods for screening voltage-gated proteins
  申请人：D.E. Shaw Research, LLC

  公开号：US10739354B2

  公开（公告）日：2020-08-11

  In one aspect, the invention relates to a method for identifying a compound which modulates the activity of a voltage-gated protein. In certain embodiments, the voltage gate protein is a voltage-gated ion channel. In certain embodiments, the voltage-gated protein is a voltage sensitive phosphatase. In certain embodiments, the voltage-gated protein used in conjunction with the methods of the invention is modified to altered permeability or voltage sensitivity.

  一方面，本发明涉及一种鉴定可调节电压门控蛋白活性的化合物的方法。在某些实施方案中，电压门控蛋白是电压门控离子通道。在某些实施方案中，电压门控蛋白是电压敏感磷酸酶。在某些实施方案中，与本发明方法结合使用的电压门控蛋白被修饰成改变通透性或电压敏感性。
• Method for labeling individual cells
  申请人：——

  公开号：US20020155520A9

  公开（公告）日：2002-10-24

  A method is provided for the labeling of individual cells. Labeling is accomplished by coating a particle with at least one dye or nucleic acid sequence encoding a marker protein. The particle is then propelled toward the cell resulting in the particle contacting the cell for a time sufficient for the dye or nucleic acid to leave the particle and enter the cell. The present method allows for the differential labeling of individual cells within dense populations of cells.

  提供了一种对单个细胞进行标记的方法。标记的方法是在颗粒上涂上至少一种染料或编码标记蛋白的核酸序列。然后将微粒推向细胞，使微粒与细胞接触足够长的时间，使染料或核酸离开微粒进入细胞。本方法可对密集细胞群中的单个细胞进行差异标记。
• High-throughput screen for identifying selective persistent sodium channels channel blockers
  申请人：Adorante S. Joseph

  公开号：US20060110778A1

  公开（公告）日：2006-05-25

  A method for identifying a selective persistent Na + channel blocker by measuring the ability of the blocker to reduce or inhibit a persistent Na + current to a greater degree than a transient Na + current. Aspects of the present method provide Na + depletion/repletion methods for identifying a selective blocker of a persistent Na + channel, hyperpolarization methods for identifying a blocker of a persistent Na+ channel, and Na/K ATPase pump inhibitor methods for identifying a selective blocker of a persistent Na + channel.

  一种通过测量阻断剂降低或抑制持久性 Na + 电流的能力比降低或抑制瞬时 Na + 电流的能力更强来鉴定选择性持久性 Na + 通道阻断剂的方法。 本方法的各个方面提供了用于鉴定持久性 Na + 通道选择性阻滞剂的 Na + 耗尽/补足方法、用于鉴定持久性 Na + 通道阻滞剂的超极化方法和用于鉴定持久性 Na + 通道选择性阻滞剂的 Na/K ATPase 泵抑制剂方法。
• METHOD FOR LABELING INDIVIDUAL CELLS
  申请人：WASHINGTON UNIVERSITY

  公开号：EP1259808A2

  公开（公告）日：2002-11-27