(1S,5R)-8-azabicyclo[3.2.1]oct-2-ene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (1S,5R)-8-azabicyclo[3.2.1]oct-2-ene
• 化学式: C₇H₁₁N
• 分子量: 109.17
• InChiKey: SURHOQQBDZIWSO-RQJHMYQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• MERTK-SPECIFIC PYRAZOLOPYRIMIDINE COMPOUNDS
  申请人：The University of North Carolina at Chapel Hill

  公开号：US20150291605A1

  公开（公告）日：2015-10-15

  The present invention includes pyrazolopyrimidine compounds of Formula I that selectively inhibit Mer tyrosine kinase (MerTK) activity and/or Tyro3 tyrosine kinase activity, and use of these pyrazolopyrimidine compounds as anti-cancer agents, immunostimulatory and immunomodulatory agents, anti-platelet agents, anti-infective agents, and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.

  本发明涉及式I的吡唑吡咯啉化合物，其选择性地抑制Mer酪氨酸激酶（MerTK）活性和/或Tyro3酪氨酸激酶活性，以及使用这些吡唑吡咯啉化合物作为抗癌剂、免疫刺激和免疫调节剂、抗血小板剂、抗感染剂，以及作为与化疗、放疗或其他肿瘤标准治疗联合使用的辅助剂。
• MERTK-SPECIFIC PYRROLOPYRIMIDINE COMPOUNDS
  申请人：The University of North Carolina at Chapel Hill

  公开号：US20150291606A1

  公开（公告）日：2015-10-15

  The present invention includes pyrrolopyrimidine compounds that selectively inhibit Mer tyrosine kinase (MerTK) activity and/or Tyro3 tyrosine kinase activity, and use of these pyrrolopyrimidine compounds as anti-cancer agents, immunostimulatory and immunomodulatory agents, anti-platelet agents, anti-infective agents, and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.

  本发明涉及一种吡咯吡咪啉化合物，该化合物可以选择性地抑制Mer酪氨酸激酶（MerTK）活性和/或Tyro3酪氨酸激酶活性，并将这些吡咯吡咪啉化合物用作抗癌剂、免疫刺激和免疫调节剂、抗血小板剂、抗感染剂以及作为与化疗、放疗或其他治疗标准相结合的辅助剂。
• US9603850B2
  申请人：——

  公开号：US9603850B2

  公开（公告）日：2017-03-28