4-(2,5-Dioxoimidazolidin-4-yl)benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 4-(2,5-Dioxoimidazolidin-4-yl)benzoic acid
• 化学式: C₁₀H₈N₂O₄
• 分子量: 220.18
• InChiKey: VJHSMOJTUYWJOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• 1,4-DIAZEPINE DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE CENTRAL NERVOUS SYSTEM
  申请人：IGT Pharma Inc.

  公开号：EP1210338A2

  公开（公告）日：2002-06-05
• [EN] NOVEL 1,4-BENZODIAZEPINE COMPOUNDS AND DERIVATIVES THEREOF<br/>[FR] NOUVEAUX COMPOSES DE 1,4-BENZODIAZEPINE ET DERIVES DE CES DERNIERS
  申请人：IGT PHARMA INC

  公开号：WO2001010846A2

  公开（公告）日：2001-02-15

  The present invention relates to therapeutically active novel 1,4-benzodiazepine compounds and derivatives thereof, of formula (I), wherein R31 or/and R32 contain at least a carboxy, or an amino group or both. Also provided is a method of preparing compounds of formula (I), and pharmaceutical compositions comprising the compounds. The novel compounds act as modulators of metabotropic glutamate receptors and, as such, are useful in treating diseases of the central nervous system related to the metabotropic glutamate receptor system.