(3,5-Dibenzoyloxy-4-fluorooxolan-2-yl)methyl benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3,5-Dibenzoyloxy-4-fluorooxolan-2-yl)methyl benzoate
• 化学式: C₂₆H₂₁FO₇
• 分子量: 464.4
• InChiKey: JOAHVPNLVYCSAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  88.1
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• MODULAR RADIOCHEMISTRY SYNTHESIS SYSTEM
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150329583A1

  公开（公告）日：2015-11-19

  A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

  一个模块化的化学生产系统包括多个模块，用于从远程位置执行化学反应，特别是放射化学化合物的反应。一个实施例包括一个反应容器，其中包括一个可移动的热源，其相对于反应容器的位置可以从远程位置控制。另一种情况是热源可能固定在某个位置，而反应瓶可以移动进入和移出热源。反应容器有一个或多个密封塞，其相对于反应容器的位置可以从远程位置控制。此外，一个或多个反应容器密封塞可以包括一个或多个通道，用于提供反应物、大气或高压气体、惰性气体、抽真空以及将反应产物从反应瓶中移出和移入，带有密封塞的反应瓶在高压下可操作。该模块化化学生产系统由模块组装而成，每个模块可以包括用于监测和控制各个模块和组装系统的操作条件传感器和控制器，可以从远程位置进行监控和控制。其他模块包括但不限于试剂储存和输送模块、柱层净化模块、微波反应模块、外部质控/分析/净化接口模块、等份取样模块、F-18 干燥模块、浓缩模块、辐射计数模块和毛细管反应器模块。
• SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSYL)CYTOSINE, SYNTHETIC INTERMEDIATE OF THIONUCLEOSIDE, AND METHOD FOR PRODUCING THE SAME
  申请人：FUJIFILM Corporation

  公开号：US20150152131A1

  公开（公告）日：2015-06-04

  A compound represented by a formula [1D] as shown below (wherein R 1A , R 1B , R 2A , R 2B , R 3A and R 3B represent a hydrogen atom, an optionally substituted C 1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

  下列的化合物，其化学式为[1D]（其中R1A、R1B、R2A、R2B、R3A和R3B代表氢原子、可选择取代的C1-6烷基等），可作为生产硫代核苷的中间体，本发明的生产方法可作为一种生产硫代核苷的方法。
• SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSYL) CYTOSINE, SYNTHETIC INTERMEDIATE OF THIONUCLEOSIDE, AND METHOD FOR PRODUCING THE SAME
  申请人：FUJIFILM Corporation

  公开号：US20160024132A1

  公开（公告）日：2016-01-28

  A compound represented by a formula [1D] as shown below (wherein R 1A , R 1B , R 2A , R 2B , R 3A and R 3B represent a hydrogen atom, an optionally substituted C 1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

  下列化学式[1D]所代表的化合物(其中R1A、R1B、R2A、R2B、R3A和R3B分别代表氢原子、可选择取代的C1-6烷基等)可用作生产硫代核苷的中间体，而本发明的生产方法则可用作生产硫代核苷的方法。
• 2'-FLUORO-4'-SUBSTITUTED NUCLEOSIDES, THE PREPARATION AND USE
  申请人：Zhengzhou University

  公开号：EP2177527A1

  公开（公告）日：2010-04-21

  The present invention provides 2'-fluorine-4'-substituted-nucleoside analogues or their pro-drugs or 5'-phosphate esters (including the pro-drugs of the 5'-phosphate esters), preparation methods and uses thereof. The compounds have the general formula as follows: wherein: R = CH3, CH, N3, C≡CH; R' = H, F; X = F, OH, NH2; Y = H, CH3, F, OH, NH2 The compounds are used in the synthesis of drugs for the treatment of virus infection, especially for the treatment of HBV, HCV or HIV infection.

  本发明提供了2'-氟-4'-取代-核苷类似物或其原药或5'-磷酸酯（包括5'-磷酸酯的原药）、制备方法及其用途。这些化合物的通式如下： 其中 R＝CH3、CH、N3、C≡CH； R' = H、F X = F、OH、NH2； Y = H、 、F、OH、NH2 这些化合物可用于合成治疗病毒感染的药物，尤其是治疗 HBV、HCV 或 HIV 感染的药物。
• INTERMEDIATE FOR SYNTHESIS OF 1-(2-DEOXY-2-FLUORO-4-THIO-beta-D-ARABINOFURANOSYL) CYTOSINE, INTERMEDIATE FOR SYNTHESIS OF THIONUCLEOSIDE, AND METHODS FOR PRODUCING THESE INTERMEDIATES
  申请人：FUJIFILM Corporation

  公开号：EP2883866A1

  公开（公告）日：2015-06-17

  A compound represented by a formula [ID] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

  由下式[ID]表示的化合物（其中 R1A、R1B、R2A、R2B、R3A 和 R3B 代表氢原子、任选取代的 C1-6 烷基等）可用作生产硫代核苷的中间体，本发明的生产方法可用作生产硫代核苷的方法。