4-(triphenyl-λ5-phosphanyl)butanenitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(triphenyl-λ5-phosphanyl)butanenitrile
• 化学式: C₂₂H₂₂NP
• 分子量: 331.4
• InChiKey: PLDWKZKXQJJRFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF<br/>[FR] NOUVEAUX DÉRIVÉS DE CYCLOSPORINE ET LEURS UTILISATIONS
  申请人：S&T GLOBAL INC

  公开号：WO2017200984A1

  公开（公告）日：2017-11-23

  A compound of the Formula (I) is disclosed: (I) or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification. Also described are a pharmaceutical composition comprising the same and a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, lung, and liver, and kindey diseases, and hair loss using the same.

  公开了化合物的公式（I）：（I）或其药学上可接受的盐，其中符号如规范中定义。还描述了包含相同化合物的药物组合物，以及使用该药物组合物治疗或预防病毒感染、炎症、干眼症、中枢神经障碍、心血管疾病、癌症、肥胖症、糖尿病、肌肉萎缩症、肺部和肝脏疾病、肾脏疾病和脱发的方法。
• METHOD FOR PRODUCING SANSHOOL
  申请人：TSUMURA & CO.

  公开号：US20130261327A1

  公开（公告）日：2013-10-03

  Provided are a method for producing a sanshool, which can produce a sanshool in a short process and with high stereoselectivity, as well as a novel diene iron complex compound that is a stable intermediate useful for the production method. The diene iron complex compound is represented by the following general formula (I): (in which A represents CO, P(R A ) 3 , CN, NO, SO(R A ) 3 , or N(R A ) 2 ; R A represents a straight chain or branched chain alkyl group having 1 to 4 carbon atoms or an aryl group having 6 to 12 carbon atoms; and one of R 1 and R 2 represents a hydrogen atom and the other one thereof represents a structure represented by the following formula (II)): (in which R represents a hydrogen atom, a hydroxyl group, or a methyl group).

  提供了一种生产山椒醛的方法，该方法可以在短时间内并具有高立体选择性地生产山椒醛，以及一种新颖的二烯基铁配合物化合物，该化合物是生产方法中有用的稳定中间体。二烯基铁配合物化合物由以下一般式(I)表示：（其中A代表CO、P(RA)3、CN、NO、SO(RA)3或N(RA)2；RA代表具有1至4个碳原子的直链或支链烷基基团或具有6至12个碳原子的芳基基团；R1和R2中的一个代表氢原子，另一个代表以下式(II)所表示的结构）：（其中R代表氢原子、羟基或甲基）。
• [EN] PERFUME COMPOSITONS CONTAINING ISOMERIC ALKADIENENITRILES<br/>[FR] COMPOSITIONS DE PARFUM CONTENANT DES ALCADIÈNENITRILES ISOMÈRES
  申请人：BEDOUKIAN RES INC

  公开号：WO2016028897A1

  公开（公告）日：2016-02-25

  A perfume composition comprising an effective amount of at least one alkadienenitrile selected from 4,8-undecadienenitrile and isomers thereof, 4,9- dodecadienenitrile and isomers thereof, and 4,10-tridecadienenitrile and isomers thereof. The isomers of 4,8-undecadienenitrile comprise Z,Z-4,8- undecadienenitrile, E,E-4,8-undecadienenitrile, and mixed Z/E isomers of 4,8- undecadienenitrile; the isomers of 4,9-dodecadienenitrile comprise Z,Z-4,9- dodecadienenitrile, E,E-4,9-dodecadienenitrile, and mixed Z/E isomers of 4,9- dodecadienenitrile; and the isomers of 4,10-tridecadienenitrile comprise Z,Z-4,10- tridecadienenitrile, E,E-4,10-tridecadienenitrile, and mixed Z/E isomers of 4,10- tridecadienenitrile. A composition comprising an effective amount of at least one alkadienenitrile selected from 4,8-undecadienenitrile and isomers thereof, 4,9- dodecadienenitrile and isomers thereof, and 4,10-tridecadienenitrile and isomers thereof. Processes for the preparation of the isomeric alkadienenitriles are provided. The isomeric alkadienenitriles have a range of fresh, citric, ozonic and floral notes of exceptional strength.

  一种香水组合物，包括有效量的至少一种烯丙腈，所述烯丙腈选择自4,8-十一碳烯腈及其异构体、4,9-十二碳烯腈及其异构体、4,10-十三碳烯腈及其异构体。4,8-十一碳烯腈的异构体包括Z,Z-4,8-十一碳烯腈、E,E-4,8-十一碳烯腈和混合的Z/E异构体；4,9-十二碳烯腈的异构体包括Z,Z-4,9-十二碳烯腈、E,E-4,9-十二碳烯腈和混合的Z/E异构体；4,10-十三碳烯腈的异构体包括Z,Z-4,10-十三碳烯腈、E,E-4,10-十三碳烯腈和混合的Z/E异构体。本发明还提供了包括有效量的至少一种烯丙腈，所述烯丙腈选择自4,8-十一碳烯腈及其异构体、4,9-十二碳烯腈及其异构体、4,10-十三碳烯腈及其异构体的组合物。本发明还提供了制备异构烯丙腈的方法。这些异构烯丙腈具有新鲜、柑橘、臭氧和花香等强烈的香气。
• PERFUME COMPOSITIONS CONTAINING ISOMERIC ALKADIENENITRILES
  申请人：BEDOUKIAN RESEARCH, INC.

  公开号：US20160052872A1

  公开（公告）日：2016-02-25

  A perfume composition comprising an effective amount of at least one alkadienenitrile selected from 4,8-undecadienenitrile and isomers thereof, 4,9-dodecadienenitrile and isomers thereof, and 4,10-tridecadienenitrile and isomers thereof. The isomers of 4,8-undecadienenitrile comprise Z,Z-4,8-undecadienenitrile, E,E-4,8-undecadienenitrile, and mixed Z/E isomers of 4,8-undecadienenitrile; the isomers of 4,9-dodecadienenitrile comprise Z,Z-4,9-dodecadienenitrile, E,E-4,9-dodecadienenitrile, and mixed Z/E isomers of 4,9-dodecadienenitrile; and the isomers of 4,10-tridecadienenitrile comprise Z,Z-4,10-tridecadienenitrile, E,E-4,10-tridecadienenitrile, and mixed Z/E isomers of 4,10-tridecadienenitrile. A composition comprising an effective amount of at least one alkadienenitrile selected from 4,8-undecadienenitrile and isomers thereof, 4,9-dodecadienenitrile and isomers thereof, and 4,10-tridecadienenitrile and isomers thereof. Processes for the preparation of the isomeric alkadienenitriles are provided. The isomeric alkadienenitriles have a range of fresh, citric, ozonic and floral notes of exceptional strength.

  一种香水组合物，包括有效量的至少一种选自4,8-十一烯腈及其异构体、4,9-十二烯腈及其异构体、4,10-十三烯腈及其异构体的烯腈。4,8-十一烯腈的异构体包括Z,Z-4,8-十一烯腈、E,E-4,8-十一烯腈和混合的Z/E异构体；4,9-十二烯腈的异构体包括Z,Z-4,9-十二烯腈、E,E-4,9-十二烯腈和混合的Z/E异构体；4,10-十三烯腈的异构体包括Z,Z-4,10-十三烯腈、E,E-4,10-十三烯腈和混合的Z/E异构体。本发明还提供了一种包含有效量的至少一种选自4,8-十一烯腈及其异构体、4,9-十二烯腈及其异构体、4,10-十三烯腈及其异构体的烯腈的组合物。本发明还提供了制备异构烯腈的方法。这些异构烯腈具有新鲜、柑橘、臭氧和花香等特别强烈的香气。
• Method for producing sanshool
  申请人：TSUMURA & CO.

  公开号：EP2644612A1

  公开（公告）日：2013-10-02

  Provided are a method for producing a sanshool, which can produce a sanshool in a short process and with high stereoselectivity, as well as a novel diene iron complex compound that is a stable intermediate useful for the production method. The diene iron complex compound is represented by the following general formula (I): (in which A represents CO, P(RA)3, CN, NO, SO(RA)3, or N(RA)2; RA represents a straight chain or branched chain alkyl group having 1 to 4 carbon atoms or an aryl group having 6 to 12 carbon atoms; and one of R1 and R2 represents a hydrogen atom and the other one thereof represents a structure represented by the following formula (II)): (in which R represents a hydrogen atom, a hydroxyl group, or a methyl group

  本发明提供了一种生产山舒尔的方法，该方法可以在短时间内生产出山舒尔，并且具有很高的立体选择性；还提供了一种新型二烯铁络合物，该化合物是一种稳定的中间体，可用于该生产方法。二烯铁络合物由以下通式（I）表示： (其中 A 代表 CO、P(RA)3、CN、NO、SO(RA)3 或 N(RA)2；RA 代表具有 1 至 4 个碳原子的直链或支链烷基或具有 6 至 12 个碳原子的芳基；R1 和 R2 中的一个代表氢原子，另一个代表下式 (II) 所表示的结构）： (其中 R 代表氢原子、羟基或甲基