2-Amino-4,4'-difluorodiphenylether | 20653-64-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Amino-4,4'-difluorodiphenylether
• 英文别名: 5-Fluoro-2-(4-fluorophenoxy)aniline
• CAS: 20653-64-9
• 化学式: C₁₂H₉F₂NO
• mdl: MFCD08687819
• 分子量: 221.206
• InChiKey: FBDRMBDSYBIOJI-UHFFFAOYSA-N

物化性质

• 沸点：
  288.3±40.0 °C(Predicted)
• 密度：
  1.295±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Amino-4,4'-difluorodiphenylether 、 2,4-二氯苯基异氰酸酯 以68%的产率得到
  参考文献：
  名称：

  TAKEUCHI, ISAO;YAMAMOTO, KAZUKO;HAMADA, YOSHIKI;ITO, TOMIYOSHI, J. PHARM. SOC. JAP., 1982, 102, N 11, 1023-1030

  摘要：

  DOI：

文献信息

• Aryl carbonyl derivatives as therapeutic agents
  申请人：——

  公开号：US20040122235A1

  公开（公告）日：2004-06-24

  This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.

  本发明涉及芳基羰基衍生物，其是葡萄糖激酶的激活剂，可用于管理、治疗、控制或辅助治疗增加葡萄糖激酶活性有益的疾病。
• PHENYLSULFAMOYL BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS
  申请人：Beke Gyula

  公开号：US20100105686A1

  公开（公告）日：2010-04-29

  The present invention relates to new sulfonamide derivatives of formula (I) wherein R 1 -R 8 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these same compounds, pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.

  本发明涉及式(I)的新磺酰胺衍生物，其中R1-R8和Z如权利要求中所定义，以及其光学对映体或外消旋体和/或盐和/或水合物和/或溶剂化物，它们是布雷地酮B1的选择性拮抗剂，用于制备这些化合物的方法、包含它们的药理学组合物以及它们在治疗或预防疼痛和炎症状况中的应用。
• NEW BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS
  申请人：Vago Istvan

  公开号：US20100087423A1

  公开（公告）日：2010-04-08

  The present invention relates to new phenylsulfamoyl benzamide derivatives of formula (I) wherein R 1 -R 5 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these compounds, to pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.

  本发明涉及新的苯磺酰苯酰胺衍生物，其化学式为(I)，其中R1-R5和Z如权利要求中所定义，以及其光学对映体或外消旋体和/或盐和/或水合物和/或溶剂合物，它们是缓激肽B1选择性拮抗剂，用于制备这些化合物的过程，包含它们的药理学组合物以及在治疗或预防疼痛和炎症症状中的应用。
• ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS
  申请人：Polisetti Dharma Rao

  公开号：US20110301158A1

  公开（公告）日：2011-12-08

  This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.

  本发明涉及芳基羰基衍生物，它们是葡萄糖激酶的活化剂，可能有助于管理、治疗、控制或辅助治疗增加葡萄糖激酶活性有益的疾病。
• New Phenylsulfamoyl Benzamide Derivatives as Bradykinin Antagonists
  申请人：Beke Gyula

  公开号：US20120295910A1

  公开（公告）日：2012-11-22

  The present invention relates to new sulfonamide derivatives of formula (I), wherein R 1 -R 8 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these same compounds, pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.

  本发明涉及公式(I)的新磺酰胺衍生物，其中R1-R8和Z如权利要求所定义，以及其光学对映体或混合物和/或盐和/或水合物和/或溶剂化物，它们是缓激肽B1选择性拮抗剂，制备这些化合物的过程，包含它们的药理学组合物以及它们在治疗或预防疼痛和炎症疾病方面的用途。