2-Ethyl-5-methyl-3,3-diphenylpyrrolidine | 57100-29-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Ethyl-5-methyl-3,3-diphenylpyrrolidine
• CAS: 57100-29-5
• 化学式: C₁₉H₂₃N
• 分子量: 265.4
• InChiKey: KHZFRCQMNPGDQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Methadone fluorescence polarization immunoassay
  申请人：ABBOTT LABORATORIES

  公开号：EP0380019A2

  公开（公告）日：1990-08-01

  A fluorescence polarization immunoassay for detecting the presence of methadone in a test sample is provided, based upon competition between methadone and a fluorescently labeled tracer for the binding sites on an antibody specific for methadone. The concentration of methadone in the sample determines the amount of tracer that binds to the antibody. The amount of tracer-antibody complex formed can be quantitatively measured and is inversely proportional to the quantity of methadone in the sample. Tracers used as reagents and immunogens used to raise antibodies for use as reagents are also disclosed.

  根据美沙酮和荧光标记示踪剂对美沙酮特异性抗体上结合位点的竞争，提供了一种荧光偏振免疫测定法，用于检测测试样品中是否含有美沙酮。样品中美沙酮的浓度决定了与抗体结合的示踪剂的量。形成的示踪剂-抗体复合物的量可以定量测量，并与样本中的美沙酮量成反比。此外，还公开了用作试剂的示踪剂和用于培养抗体以用作试剂的免疫原。
• Immunogens for raising antibodies useful in methadone fluorescence polarization immunoassay
  申请人：ABBOTT LABORATORIES

  公开号：EP0662613A1

  公开（公告）日：1995-07-12

  An immunogen useful in eliciting antibodies for determining the presence or amount of methadone in a test sample, comprising the structure: wherein:    R and R' represent a spacer group consisting of from 0 to 15 carbon atoms and heteroatoms, including not more than six heteroatoms, arranged in a straight or branched chain, saturated or unsaturated, with the proviso that not more than two heteroatoms may be linked in sequence and, in the case of R, that branchings may occur only on carbon atoms;    x is 0 or 1;    M is a linking group selected from C=O, -NH-, O-C=O, N-C=O, and N-C=S; and    Q is an immunogenic carrier. Haptens used to make the immunogens are also disclosed.

  一种用于激发抗体以确定测试样品中是否存在美沙酮或其含量的免疫原，包括以下结构： 其中 R和R'代表由0至15个碳原子和杂原子（包括不超过6个杂原子）组成的间隔基团，排列成饱和或不饱和的直链或支链，但不得有两个以上的杂原子依次相连，在R的情况下，只能在碳原子上发生分支； x 为 0 或 1； M 是一个连接基团，选自 C=O、-NH-、O-C=O、N-C=O 和 N-C=S；以及 Q 是免疫原载体。用于制造免疫原的巯基也已公开。
• IMMUNOASSAYS EMPLOYING GENERIC ANTI-HAPTEN ANTIBODIES AND MATERIALS FOR USE THEREIN
  申请人：Abbott Laboratories

  公开号：EP0731917A1

  公开（公告）日：1996-09-18
• METHADONE DERIVATIVES AND PROTEIN AND POLYPEPTIDE METHADONE DERIVATIVE CONJUGATES AND LABELS
  申请人：BIOSITE DIAGNOSTICS INC.

  公开号：EP0827502B1

  公开（公告）日：2000-11-22
• CONJUGATES AND SPECIFIC IMMUNOASSAYS FOR THE METHADONE METABOLITE 2-ETHYLIDINE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE
  申请人：Microgenics Corporation

  公开号：EP0931062B1

  公开（公告）日：2004-11-17