p-Tolylethanamine, N-[4-hydroxyhydrocinnamoyl]-

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-Tolylethanamine, N-[4-hydroxyhydrocinnamoyl]-
• 英文别名: 3-(4-hydroxyphenyl)-N-[2-(4-methylphenyl)ethyl]propanamide
• 化学式: C₁₈H₂₁NO₂
• 分子量: 283.4
• InChiKey: MYLKGBPGQWGNMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Para-coumaric acid or para-hydroxycinnamic acid derivatives and their use in cosmetic or dermatological compositions
  申请人：Okombi Sabrina

  公开号：US20070183996A1

  公开（公告）日：2007-08-09

  The invention relates to the use of para-coumaric acid or para-hydroxycinnamic acid derivatives in cosmetic or dermatological compositions, specifically to the use of at least one compound derived from para-coumaric acid having a general formula (I) below: in which, especially, Z represents an oxygen or an —NH— group; X and Y are identical and each represent a CH or CH 2 group, as an active principle with depigmenting, free-radical-scavenging and/or antiinflammatory activity. The invention also relates to the use of the above compounds for cosmetic care or for the preparation of a pharmaceutical composition, especially for depigmenting an area of skin, having antiradical and/or antiinflammatory activity.

  该发明涉及对苯对羟基肉桂酸或对羟基肉桂酸衍生物在化妆品或皮肤科学组合物中的使用，具体地涉及至少一种源自苯对羟基肉桂酸的化合物的使用，其具有下面的一般式(I)：其中，特别地，Z代表氧原子或—NH—基团；X和Y相同，各代表一个CH或CH2基团，作为具有脱色、自由基清除和/或抗炎活性的活性原理。该发明还涉及上述化合物在化妆护理或制备药用组合物中的使用，特别是用于脱色皮肤区域，具有抗自由基和/或抗炎活性。
• Para-Coumaric Acid or Para-Hydroxycinnamic Acid Derivatives and Their Use in Cosmetic or Dermatological Compositions
  申请人：Okombi Sabrina

  公开号：US20110237551A1

  公开（公告）日：2011-09-29

  The invention relates to the use of para-coumaric acid or para-hydroxycinnamic acid derivatives in cosmetic or dermatological compositions, specifically to the use of at least one compound derived from para-coumaric acid having a general formula (I) below: in which, especially, Z represents an oxygen or an —NH— group; X and Y are identical and each represent a CH or CH 2 group, as an active principle with depigmenting, free-radical-scavenging and/or antiinflammatory is activity. The invention also relates to the use of the above compounds for cosmetic care or for the preparation of a pharmaceutical composition, especially for depigmenting an area of skin, having antiradical and/or antiinflammatory activity.

  本发明涉及对香豆酸或对羟基肉桂酸衍生物在化妆品或皮肤科组合物中的使用，具体地，涉及使用至少一种从对香豆酸衍生的化合物，其具有下列通式（I）：其中，特别地，Z表示氧或—NH—基团；X和Y相同，分别表示CH或CH2基团，作为具有脱色、自由基清除和/或抗炎活性的活性原理的用途。本发明还涉及上述化合物在化妆品护理或制备药物组合物中的使用，特别用于脱色皮肤区域，具有抗自由基和/或抗炎活性。
• Para-Coumaric Acid or Para-Hydroxycinnamic Acid Derivatives and their Use in Cosmetic or Dermatological Compositions
  申请人：Universite Joseph Fourier-Grenoble 1.

  公开号：US20130272983A1

  公开（公告）日：2013-10-17

  The invention relates to the use of para-coumaric acid or para-hydroxycinnamic acid derivatives in cosmetic or dermatological compositions, specifically to the use of at least one compound derived from para-coumaric acid having a general formula (I) below: in which, especially, Z represents an oxygen or an —NH— group; X and Y are identical and each represent a CH or CH 2 group, as an active principle with depigmenting, free-radical-scavenging and/or antiinflammatory activity. The invention also relates to the use of the above compounds for cosmetic care or for the preparation of a pharmaceutical composition, especially for depigmenting an area of skin, having antiradical and/or antiinflammatory activity.

  本发明涉及对于化妆品或皮肤科组合物中使用对香豆酸或对羟基肉桂酸衍生物的使用，具体地涉及使用至少一种源自对香豆酸的化合物，其具有下列一般式(I)：其中，尤其是，Z代表氧或—NH—基团；X和Y相同，分别代表CH或CH2基团，作为具有脱色、自由基清除和/或抗炎活性的活性原理。本发明还涉及上述化合物在化妆品护理或制备药物组合物方面的使用，尤其是用于脱色皮肤区域，具有抗自由基和/或抗炎活性。
• COMPOUNDS FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES, IMMUNO-ALLERGICAL DISEASES AND ORGAN OR TISSUE TRANSPLANTATION REJECTION
  申请人：Novaremed Ltd.

  公开号：EP1546088B1

  公开（公告）日：2014-12-17
• US4908322A
  申请人：——

  公开号：US4908322A

  公开（公告）日：1990-03-13