3-[1,1'-biphenyl]-4-yl-1H-pyrazol-5-ylamine | 208519-16-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[1,1'-biphenyl]-4-yl-1H-pyrazol-5-ylamine
• 英文别名: 5-(4-phenylphenyl)-1H-pyrazol-3-amine
• CAS: 208519-16-8
• 化学式: C₁₅H₁₃N₃
• mdl: MFCD00981600
• 分子量: 235.28
• InChiKey: PMNPUUUDKHRGAH-UHFFFAOYSA-N

物化性质

• 沸点：
  550.4±38.0 °C(Predicted)
• 密度：
  1.213±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT

文献信息

• NOVEL UREA DERIVATIVES
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0955293A1

  公开（公告）日：1999-11-10

  The present invention relates to a compound represented by the general formula [I]: wherein A represents a nitrogen atom or a group represented by C-R5; Ar1 represents an aryl group which may have a substituent selected from the group consisting of a halogen atom and lower alkyl and lower haloalkyl groups; Ar2 represents an aryl or heteroaryl group which may have a substituent selected from the group consisting of a halogen atom and lower alkyl, lower alkenyl, lower haloalkyl, lower alkoxy, lower alkylthio, lower alkylamino, lower dialkylamino and aryl groups; R1 represents a hydrogen atom, a lower alkyl group or a bond formed by linking to R5; R2 represents a hydrogen atom or a lower alkyl group; R3 and R4 may be the same or different and each represents a hydrogen atom or a lower alkyl group, or R3 and R4 are linked to each other to form an alkylene group containing 2 to 4 carbon atoms which may have a lower alkyl group; and R5 represents a hydrogen atom or a hydroxyl, lower alkyl or lower alkoxy group or a bond formed by linking to R1, or its salt, a process for its preparation and an agent for the treatment of bulimia, obesity or diabetes comprising it as an active ingredient.

  本发明涉及通式[I]所代表的化合物： 其中A代表氮原子或由C-R5代表的基团；Ar1代表芳基，其取代基可选自卤素原子和低级烷基及低级卤代烷基组成的组；Ar2代表芳基或杂芳基，其取代基可选自卤素原子和低级烷基、低级烯基、低级卤代烷基、低级烷氧基、低级烷硫基、低级烷基氨基、低级二烷基氨基和芳基组成的组；R1 代表氢原子、低级烷基或与 R5 连接形成的键；R2 代表氢原子或低级烷基；R3 和 R4 可以相同或不同，且各自代表氢原子或低级烷基，或 R3 和 R4 相互连接形成含 2 至 4 个碳原子的亚烷基，该亚烷基可能具有低级烷基；以及 R5 代表氢原子或羟基、低级烷基或低级烷氧基或与 R1 连接形成的键、 或其盐类，其制备方法和治疗贪食症、肥胖症或糖尿病的制剂，其活性成分包括它。
• UREA DERIVATIVES
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0955293B1

  公开（公告）日：2003-03-19
• US6043246A
  申请人：——

  公开号：US6043246A

  公开（公告）日：2000-03-28