2-(3H-imidazol-4-ylmethoxy)-isoindol-1,3-dione | 38939-71-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(3H-imidazol-4-ylmethoxy)-isoindol-1,3-dione
• 英文别名: 2-(1H-imidazol-4-ylmethoxy)-1,3-dihydro-2H-isoindole-1,3-dione；2-(1H-imidazol-5-ylmethoxy)isoindole-1,3-dione
• CAS: 38939-71-8
• 化学式: C₁₂H₉N₃O₃
• 分子量: 243.222
• InChiKey: UGFYBIIUXQGMSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  75.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(3H-imidazol-4-ylmethoxy)-isoindol-1,3-dione 生成 N-((N-tritylimidazol-4-yl)methoxy)phthalimide
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  N-羟基邻苯二甲酰亚胺 、 1H-咪唑-2-甲醇盐酸盐 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以22%的产率得到2-(3H-imidazol-4-ylmethoxy)-isoindol-1,3-dione
  参考文献：
  名称：

  [EN] 6-AZAINDOLE COMPOUND
  [FR] COMPOSE DE 6-AZAINDOLE

  摘要：

  公开号：

  WO2005097129A3

文献信息

• Cephalosporin derivatives
  申请人：Daiichi Seiyaku Co., Ltd.

  公开号：US04603198A1

  公开（公告）日：1986-07-29

  Novel cephalosporin derivatives and physiologically acceptable salts thereof which are useful as antibacterial agents against gram-negative and gram-positive bacteria, and a process for preparing these compounds are disclosed.

  本发明公开了新型头孢菌素衍生物及其生理上可接受的盐，其可用作革兰氏阴性和革兰氏阳性细菌的抗菌剂，并公开了制备这些化合物的方法。
• 4-Phenylamino-benzaldoxime derivatives and uses thereof as mitogen-activated protein kinase kinase (mek) inhibitors
  申请人：Isshiki Yoshiaki

  公开号：US20070105859A1

  公开（公告）日：2007-05-10

  A compound of the present invention, or a pharmaceutically acceptable salt thereof is indicated by formula (1) below: wherein, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , Q, R 8 , and R 9 have the same meanings as R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , Q, R 8 , and R 9 in the specification.

  本发明的化合物或其药学上可接受的盐由下式（1）表示：其中，R1、R2、R3、R4、R5、R6、Q、R8和R9在说明书中具有与R1、R2、R3、R4、R5、R6、Q、R8和R9相同的含义。
• 6-Azaindole Compound
  申请人：Horiguchi Yoshiaki

  公开号：US20080064715A1

  公开（公告）日：2008-03-13

  A compound represented by the formula wherein R 1 , R 2 , R 3 and R 6 are the same or different and each is a hydrogen atom or a substituent; one of R 4 and R 5 is a hydrogen atom and the other is a group represented by the formula: —C(═X)—R 7 wherein X is N—O—R 8 or N—NH—R 9 wherein R 8 and R 9 are the same or different and each is a hydrogen atom or a group bonded via a carbon atom; and R 7 is a hydrogen atom or a substituent, and the like and a salt thereof have a superior IκB kinase inhibitory activity, and useful as pharmaceutical agents such as agents for preventing or treating diabetes and the like.

  一种化合物的化学式为其中R1、R2、R3和R6相同或不同，每个都是氢原子或取代基；R4和R5中的一个是氢原子，另一个是代表公式的基团：—C(═X)—R7，其中X为N—O—R8或N—NH—R9，R8和R9相同或不同，每个都是氢原子或通过碳原子键合的基团；而R7是氢原子或取代基等。该化合物及其盐具有优异的IκB激酶抑制活性，并可用作预防或治疗糖尿病等药物。
• 4-phenylamino-benzaldoxime derivatives and uses thereof as mitogen-activated protein kinase kinase (MEK) inhibitors
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US08084645B2

  公开（公告）日：2011-12-27

  A compound of the present invention, or a pharmaceutically acceptable salt thereof is indicated by formula (1) below: wherein, R1, R2, R3, R4, R5, R6, Q, R8, and R9 have the same meanings as R1, R2, R3, R4, R5, R6, Q, R8, and R9 in the specification.

  本发明的化合物或其药学上可接受的盐，由下式（1）表示：其中，R1、R2、R3、R4、R5、R6、Q、R8和R9在说明书中具有与R1、R2、R3、R4、R5、R6、Q、R8和R9相同的含义。
• 6-azaindole compound
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US07608627B2

  公开（公告）日：2009-10-27

  A compound represented by the formula wherein R1, R2, R3 and R6 are the same or different and each is a hydrogen atom or a substituent; one of R4 and R5 is a hydrogen atom and the other is a group represented by the formula: —C(═X)—R7 wherein X is N—O—R8 or N—NH—R9 wherein R8 and R9 are the same or different and each is a hydrogen atom or a group bonded via a carbon atom; and R7 is a hydrogen atom or a substituent, and the like and a salt thereof have a superior IκB kinase inhibitory activity, and useful as pharmaceutical agents such as agents for preventing or treating diabetes and the like.

  该化合物的化学式表示为其中R1，R2，R3和R6相同或不同，每个都是氢原子或取代基; R4和R5中的一个是氢原子，另一个是表示为公式的基团：—C（═X）—R7，其中X为N—O—R8或N—NH—R9，其中R8和R9相同或不同，每个都是氢原子或通过碳原子连接的基团; R7是氢原子或取代基，类似物及其盐具有优良的IκB激酶抑制活性，并可用作预防或治疗糖尿病等药物。