N-[3-carbamoyl-4,5-dimethyl-thien-2-yl]3,4-methylenedioxycinnamic amide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: N-[3-carbamoyl-4,5-dimethyl-thien-2-yl]3,4-methylenedioxycinnamic amide
• 英文别名: 2-{[3-(1,3-Benzodioxol-5-yl)acryloyl]amino}-4,5-dimethyl-3-thiophenecarboxamide；2-[[(E)-3-(1,3-benzodioxol-5-yl)prop-2-enoyl]amino]-4,5-dimethylthiophene-3-carboxamide
• 化学式: C₁₇H₁₆N₂O₄S
• 分子量: 344.391
• InChiKey: XFPTYJQHVHMUIB-GQCTYLIASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1294707A2

  公开（公告）日：2003-03-26
• US6414013B1
  申请人：——

  公开号：US6414013B1

  公开（公告）日：2002-07-02
• [EN] THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM<br/>[FR] DERIVES DE THIOPHENE ACTIFS EN TANT QU'INHIBITEURS DE KINASE, LEUR PROCEDE DE PREPARATION, ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：PHARMACIA & UPJOHN SPA

  公开号：WO2001098290A2

  公开（公告）日：2001-12-27

  Compounds which are 3-aminocarbonyl-2-carboxamido-thiophene derivatives or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.