2(1H)-Pyridone, 1-ethyl-4-methyl- | 19006-62-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2(1H)-Pyridone, 1-ethyl-4-methyl-
• 英文别名: 1-ethyl-4-methylpyridin-2-one
• CAS: 19006-62-3
• 化学式: C₈H₁₁NO
• 分子量: 137.18
• InChiKey: KCPRFGZSBHBAJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Thiazole derivatives
  申请人：Nakajima Takao

  公开号：US20070105919A1

  公开（公告）日：2007-05-10

  (Wherein n is an integer of from 0 to 3; R 1 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, or a substituted or unsubstituted aromatic heterocyclic group; R 2 is halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted aromatic heterocyclic group, —COR 8 , or the like; R 3 and R 4 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, —COR 12 , or the like) For example, provided are adenosine A 2A receptor antagonists comprising, as the active ingredient, a thiazole derivative represented by a general formula (I), or a pharmaceutically acceptable salt thereof, and the like.

  其中n为0至3的整数；R1代表取代或未取代的环烷基、取代或未取代的芳基、取代或未取代的脂环杂环基或取代或未取代的芳香杂环基；R2代表卤素、取代或未取代的低碳基、取代或未取代的芳基、取代或未取代的脂环杂环基、取代或未取代的芳香杂环基、-COR8或类似物；R3和R4可以相同也可以不同，每个代表氢原子、取代或未取代的低碳基、取代或未取代的芳基烷基、-COR12或类似物。例如，提供了包含噻唑衍生物的腺苷A2A受体拮抗剂作为活性成分，其表示为通式（I）或其药学上可接受的盐等。
• THIAZOLE DERIVATIVES
  申请人：Nakajima Takao

  公开号：US20110105486A1

  公开（公告）日：2011-05-05

  Wherein n is an integer of from 0 to 3; R 1A is a 5-membered aromatic heterocyclic group containing at least one oxygen atom; R 2A is —COR 8 (wherein R 8 is aryl); R 3A is hydrogen or lower alkyl; and R 12 represents cycloalkyl, aryl, aralkyl, alicyclic heterocyclic group, aromatic heterocyclic group, alicyclic hetocyclic-alkyl, or aromatic heterocyclic-alkyl, and R 1A , R 2A , R 3A and R 12 are individually optionally substituted.

  其中n是0到3的整数；R1A是一个含有至少一个氧原子的5-成员芳香杂环基团；R2A是-COR8（其中R8是芳香基）；R3A是氢或较低的烷基；而R12代表环烷基，芳香基，芳基烷基，脂环杂环基团，芳香杂环基团，脂环杂环烷基或芳香杂环烷基，R1A，R2A，R3A和R12都可以个别地选择性地被取代。
• Fused Heterocyclic Compounds as Selective BMP Inhibitors
  申请人：VANDERBILT UNIVERSITY

  公开号：US20160068525A1

  公开（公告）日：2016-03-10

  The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.

  本发明提供了BMP信号通路的小分子抑制剂。这些化合物可用于调节细胞生长、分化、增殖和凋亡，因此可用于治疗与BMP信号通路相关的疾病或情况，包括炎症、心血管疾病、血液病、癌症和骨骼疾病，以及用于调节细胞分化和/或增殖。
• NOVEL COMPOUNDS THAT ARE ERK INHIBITORS
  申请人：MERCK SHARP & DOHME CORP.

  公开号：EP3536319A1

  公开（公告）日：2019-09-11

  Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof, wherein: A is a five membered monocyclic heteroaryl ring; and B is a monocyclic heterocycloalkyl ring, or a monocyclic heterocycloalkenyl ring, or a bridged monocyclic heterocycloalkyl ring, or a fused (monocyclic heterocycloalkyl ring)cyclopropyl ring. Also disclosed are methods of treating cancer using the compounds of formula (1).

  所公开的是式 (1) 的 ERK 抑制剂： 及其药学上可接受的盐类，其中A 是五元单环杂芳基环；B 是单环杂环烷基环、或单环杂环烯基环、或桥接单环杂环烷基环、或融合（单环杂环烷基环）环丙基环。还公开了使用式（1）化合物治疗癌症的方法。
• OXADIAZOLINE COMPOUND OR SALT THEREOF, AGRICULTURAL OR HORTICULTURAL BACTERICIDE CONTAINING SAID COMPOUND, AND USE METHOD THEREFOR
  申请人：Nihon Nohyaku Co., Ltd.

  公开号：EP3835290A1

  公开（公告）日：2021-06-16

  Development of a novel agricultural or horticultural bactericide is desired because considerable damage by diseases is still caused to agricultural and horticultural production and the like and because of, for example, damage by diseases resistant to conventional chemicals. The present invention provides an agricultural or horticultural bactericide and a use method therefor, the bactericide including, as an active ingredient, a compound represented by general formula (I) or a salt thereof: [In formula (I), X1, X2, X3, and X4 each represent a hydrogen atom, etc.; A, B, and Y each represent a single bond, a carbonyl group, etc.; Q represents a C1-6 alkyl group, a heterocycle, etc.; and R5 and R6 each represent a hydrogen atom, a C1-6 alkyl group, etc.]

  由于病害仍然对农业和园艺生产等造成相当大的损害，而且例如由于病害对常规化学品具有抗药性，因此需要开发一种新型的农业或园艺杀菌剂。 本发明提供了一种农业或园艺杀菌剂及其使用方法，该杀菌剂包括通式（I）所代表的化合物或其盐作为活性成分： 式（I）中，X1、X2、X3 和 X4 分别代表氢原子等；A、B 和 Y 分别代表单键、羰基等；Q 代表 C1-6 烷基、杂环等；R5 和 R6 分别代表氢原子、C1-6 烷基等。