2,4,5,6-Tetramethylpyridin-3-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,4,5,6-Tetramethylpyridin-3-ol
• 化学式: C₉H₁₃NO
• mdl: MFCD00778715
• 分子量: 151.21
• InChiKey: HKNDPWYEACZSHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.444
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Compounds - 801
  申请人：Alcaraz Lilian

  公开号：US20110053909A1

  公开（公告）日：2011-03-03

  Spirocyclic amide derivatives of formula I wherein ArCH 2 CH 2 NH— represents a β-adrenoceptor binding group, processes for their preparation, pharmaceutical compositions containing them, a process for preparing such pharmaceutical compositions, their use in therapy, and intermediates for use in their preparation.

  式I的螺环酰胺衍生物，其中ArCH2CH2NH—代表β-肾上腺素受体结合基团，其制备方法，含有它们的药物组合物，制备这种药物组合物的方法，它们在治疗中的应用，以及用于其制备的中间体。
• HETEROARYLAMIDOPYRIDINOL DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF AUTOIMMUNE DISEASE
  申请人：Innovo Therapeutics Inc.

  公开号：EP4008718A1

  公开（公告）日：2022-06-08

  The present invention relates to a heteroarylamidopyridinol derivative and a pharmaceutical composition comprising same as an active ingredient for prevention or treatment of an autoimmune disease, specifically, inflammatory bowel disease, rheumatoid arthritis, etc. The heteroarylamidopyridinol derivative exhibits an excellent effect of inhibiting TNF-α- or IL-6-induced monocyte adhesion to gut epithelial cells and is proven to have a therapeutic effect on inflammatory bowel disease and rheumatoid arthritis in vivo. Thus, the heteroarylamidopyridinol derivative can be advantageously used for treatment of an autoimmune disease, specifically, inflammatory bowel disease or rheumatoid arthritis.

  本发明涉及一种杂芳基酰胺吡啶醇衍生物和一种药物组合物，其中包含杂芳基酰胺吡啶醇衍生物作为活性成分，用于预防或治疗自身免疫性疾病，特别是炎症性肠病、类风湿性关节炎等。杂芳基酰胺基吡啶醇衍生物在抑制 TNF-α- 或 IL-6 诱导的单核细胞粘附到肠道上皮细胞方面表现出卓越的效果，并被证明对体内的炎症性肠病和类风湿性关节炎有治疗作用。因此，杂芳基酰胺基吡啶醇衍生物可以很好地用于治疗自身免疫性疾病，特别是炎症性肠病或类风湿性关节炎。
• US8455483B2
  申请人：——

  公开号：US8455483B2

  公开（公告）日：2013-06-04
• US8476265B2
  申请人：——

  公开号：US8476265B2

  公开（公告）日：2013-07-02
• [EN] NOVEL 6-HETEROARYLAMINO-2,4,5-TRIMETHYLPYRIDIN-3-OL COMPOUND, OR PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY BOWEL DISEASES AND AUTOIMMUNE DISEASES COMPRISING SAME<br/>[FR] NOUVEAU COMPOSÉ 6-HÉTÉROARYLAMINO-2,4,5-TRIMÉTHYLPYRIDINE-3-OL, OU COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES INTESTINALES INFLAMMATOIRES ET DE MALADIES AUTO-IMMUNES LE COMPRENANT<br/>[KO] 신규한 6-헤테로아릴아미노-2,4,5-트라이메틸피리딘-3-올 화합물, 또는 이를 포함하는 염증성 장질환 및 자가면역 질환의 예방 또는 치료용 약학 조성물
  申请人：UNIV YEUNGNAM RES COOPERATION FOUNDATION

  公开号：WO2019194556A1

  公开（公告）日：2019-10-10

  본 발명은 신규한 6-헤테로아릴아미노-2,4,5-트라이메틸피리딘-3-올 화합물, 또는 이의 약제학적으로 허용 가능한 염에 관한 것이다. 구체적으로, 본 발명은 염증성 장질환 및 자가면역 질환을 예방 또는 치료하는 효과를 갖는 신규한 6-헤테로아릴아미노-2,4,5-트라이메틸피리딘-3-올 화합물, 또는 이의 약제학적으로 허용 가능한 염에 관한 것이다.