N-(1H-Tetrazol-5-yl)-2-chinoxalincarboxamid | 55495-54-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(1H-Tetrazol-5-yl)-2-chinoxalincarboxamid
• 英文别名: quinoxaline-2-carboxylic acid 1(2)H-tetrazol-5-ylamide；N(1H tetrazol-5-yl)-2-quinoxalinecarboxamide；N-(2H-tetrazol-5-yl)quinoxaline-2-carboxamide
• CAS: 55495-54-0
• 化学式: C₁₀H₇N₇O
• 分子量: 241.212
• InChiKey: LDVWVNHRJCSDMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-氨基四氮唑 、 2-喹喔啉羧酸 、 N,N'-羰基二咪唑 以 四氢呋喃 、 N-甲基乙酰胺 、 水 为溶剂， 生成 N-(1H-Tetrazol-5-yl)-2-chinoxalincarboxamid
  参考文献：
  名称：

  Quinoxaline-2-carboxamidotetrazoles

  摘要：

  通式I的化合物：##STR1##及其药用可接受的盐，其中：A代表基团##STR2##或基团##STR3##通过氮原子连接到相邻的苯环上，其中R.sub.1代表氢原子，或者一个烷基基团，该基团可以选择性地被一个或多个芳基、芳氧基、烷氧基、酰氧基、氨基、烷基氨基、二烷基氨基或羟基取代，或者代表烯基基团；R.sub.2代表氢原子，卤原子或烷基基团或基团OR.sub.3，其中R.sub.3是氢原子或烷基基团，该基团可以选择性地被一个或多个芳基、芳氧基、烷氧基、酰氧基、羟基、氨基、烷基氨基或二烷基氨基取代，或者基团NR.sub.4 R.sub.5，其中R.sub.4和R.sub.5可以相同也可以不同，并具有R.sub.1或R.sub.4和R.sub.5给定的含义，或者R.sub.4和R.sub.5连同氮原子形成一个可能含有额外杂原子的5或6元杂环的环；R.sub.6和R.sub.7可以相同也可以不同，代表氢原子，或卤原子或烷基基团或基团OR.sub.3或上述定义的基团NR.sub.4 R.sub.5。这些化合物具有治疗主要由抗原与变应原抗体结合引起的病症的活性。

  公开号：

  US03997535A1

文献信息

• METAL POLISHING SLURRY AND CHEMICAL MECHANICAL POLISHING METHOD
  申请人：YOSHIKAWA Masaru

  公开号：US20090203215A1

  公开（公告）日：2009-08-13

  A metal polishing slurry which is capable of simultaneously realizing a high polishing speed and reduced dishing in the polishing of a subject to be polished is provided. The metal polishing slurry includes a compound represented by the following general formula (1): wherein X represents a heterocyclic group containing at least one nitrogen atom, Y represents hydrogen atom, an aliphatic hydrocarbon group, an aryl group, or a —C(═O)Z′ wherein Z′ is as defined for Z, and Z represents hydrogen atom, an optionally substituted aliphatic hydrocarbon group, an optionally substituted aryl group, an optionally substituted heterocyclic group, —NZ 1 Z 2 , or —OZ 3 wherein Z 1 , Z 2 , and Z 3 independently represent hydrogen atom, an optionally substituted aliphatic hydrocarbon group, an optionally substituted aryl group, or an optionally substituted heterocyclic group, with the proviso that Y and Z may together form a ring; an oxidizing agent; and an organic acid.
• Quinoxaline-2-carboxamidotetrazoles
  申请人：Allen & Hanburys Limited

  公开号：US03997535A1

  公开（公告）日：1976-12-14

  Compounds of the general formula I: ##STR1## and pharmaceutically acceptable salts thereof in which: A represents the group ##STR2## or the group ##STR3## linked to the adjacent benzene ring through the nitrogen atom, in which R.sub.1 represents a hydrogen atom, or an alkyl group which may optionally be substituted by one or more aryl, aryloxy, alkoxy, acyloxy, amino, alkylamino, dialkylamino or hydroxy groups or represents an alkenyl group; R.sub.2 represents a hydrogen atom, a halogen atom or an alkyl group or the group OR.sub.3, where R.sub.3 is a hydrogen atom or an alkyl group which may optionally be substituted by one or more aryl, aryloxy, alkoxy, acyloxy, hydroxy, amino, alkylamino or dialkylamino groups or the group NR.sub.4 R.sub.5 where R.sub.4 and R.sub.5 may be the same or different and have the meanings given for R.sub.1 or R.sub.4 and R.sub.5 together with the nitrogen atom form a 5 or 6 membered heterocyclic ring which may optionally contain additional hetero atoms; R.sub.6 and R.sub.7 which may be the same or different represent a hydrogen atom, or a halogen atom or an alkyl group or the group OR.sub.3 or the group NR.sub.4 R.sub.5 as defined above. These compounds have activity as for the treatment of conditions caused primarily by the combination of an antigen with a reaginic antibody.

  通式I的化合物：##STR1##及其药用可接受的盐，其中：A代表基团##STR2##或基团##STR3##通过氮原子连接到相邻的苯环上，其中R.sub.1代表氢原子，或者一个烷基基团，该基团可以选择性地被一个或多个芳基、芳氧基、烷氧基、酰氧基、氨基、烷基氨基、二烷基氨基或羟基取代，或者代表烯基基团；R.sub.2代表氢原子，卤原子或烷基基团或基团OR.sub.3，其中R.sub.3是氢原子或烷基基团，该基团可以选择性地被一个或多个芳基、芳氧基、烷氧基、酰氧基、羟基、氨基、烷基氨基或二烷基氨基取代，或者基团NR.sub.4 R.sub.5，其中R.sub.4和R.sub.5可以相同也可以不同，并具有R.sub.1或R.sub.4和R.sub.5给定的含义，或者R.sub.4和R.sub.5连同氮原子形成一个可能含有额外杂原子的5或6元杂环的环；R.sub.6和R.sub.7可以相同也可以不同，代表氢原子，或卤原子或烷基基团或基团OR.sub.3或上述定义的基团NR.sub.4 R.sub.5。这些化合物具有治疗主要由抗原与变应原抗体结合引起的病症的活性。