N-isobutyl-2-methoxybenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-isobutyl-2-methoxybenzamide
• 英文别名: 2-methoxy-N-(2-methylpropyl)benzamide
• 化学式: C₁₂H₁₇NO₂
• mdl: MFCD01152876
• 分子量: 207.27
• InChiKey: PWMLCRMVXOCZCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE<br/>[FR] DÉGRADATION DE LA TYROSINE KINASE DE BRUTON (BTK) PAR CONJUGAISON D'INHIBITEURS DE BTK AVEC UN LIGAND DE LIGASE E3 ET PROCÉDÉS D'UTILISATION
  申请人：BEIGENE LTD

  公开号：WO2022143856A1

  公开（公告）日：2022-07-07

  Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

  本文披露了一种新型的双功能化合物，它由BTK抑制剂部分与E3连接配体部分共价结合而成，其功能是将目标蛋白质招募到E3泛素连接酶进行降解，并提供了其制备方法和用途。
• [EN] (R) -GLUTARIMIDE CRBN LIGANDS AND METHODS OF USE<br/>[FR] LIGANDS DE (R)-GLUTARIMIDE CRBN ET PROCÉDÉS D'UTILISATION
  申请人：BEIGENE LTD

  公开号：WO2022268052A1

  公开（公告）日：2022-12-29

  Disclosed herein are compounds for binding and modulating the activity of cereblon (CRBN), and methods of use. The present invention also provides compounds that can be used as synthetic intermediates in the preparation of bifunctional compounds for use in targeted protein degradation. The present compounds are thus useful for the treatment or prophylaxis tumors and cancer.

  本文披露了用于结合和调节小脑素（CRBN）活性的化合物，以及使用方法。本发明还提供了可用作合成双功能化合物的中间体的化合物，用于靶向蛋白质降解。因此，本化合物对于治疗或预防肿瘤和癌症是有用的。
• FORMULATIONS
  申请人：Bell Gordon Alistair

  公开号：US20120184438A1

  公开（公告）日：2012-07-19

  This invention relates to agrochemical compositions comprising a benzamide compound of formula (I) where R 1 is fluoro, methoxy or C 1-4 alkyl; R 2 and R 3 are each independently optionally substituted C 1-6 alkyl or optionally substituted C 2-6 alkenyl; or R 3 is hydrogen and R 3 is optionally substituted C 5-8 alkyl or optionally substituted C 4-6 alkenyl or optionally substituted benzyl; or R 2 and R 3 and the nitrogen atom to which they are both attached together form an optionally substituted 5-, 6- or 7-membered ring, which ring optionally contains at least one further heteroatom selected from O, N and S; to the use of those benzamide compounds as solvents; to certain novel compounds of formula (I); and to a process for preparing those novel compounds.
• US7521158B2
  申请人：——

  公开号：US7521158B2

  公开（公告）日：2009-04-21
• [EN] FORMULATIONS<br/>[FR] FORMULATIONS
  申请人：SYNGENTA LTD

  公开号：WO2011010082A2

  公开（公告）日：2011-01-27

  This invention relates to agrochemical compositions comprising a benzamide compound of formula (I) where R1 is fluoro, methoxy or C1-4 alkyl; R2 and R3 are each independently optionally substituted C1-6 alkyl or optionally substituted C2-6 alkenyl; or R3 is hydrogen and R3 is optionally substituted C5-8 alkyl or optionally substituted C4-6 alkenyl or optionally substituted benzyl; or R2 and R3 and the nitrogen atom to which they are both attached together form an optionally substituted 5-, 6- or 7-membered ring, which ring optionally contains at least one further heteroatom selected from O, N and S; to the use of those benzamide compounds as solvents; to certain novel compounds of formula (I); and to a process for preparing those novel compounds.