2-phenoxy-2-phenyl-propionic acid | 34221-03-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-phenoxy-2-phenyl-propionic acid
• 英文别名: 2-Phenoxy-2-phenyl-propionsaeure；2-Phenyl-2-phenoxypropionic acid；2-phenoxy-2-phenylpropanoic acid
• CAS: 34221-03-9
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.274
• InChiKey: DHCJQRNKEXCLCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (+/-)-2-phenoxy-2-phenyl-propionic acid ethyl ester 在 sodium hydroxide 作用下， 生成 2-phenoxy-2-phenyl-propionic acid
  参考文献：
  名称：

  Assessment of ampulla (Takotsubo) cardiomyopathy with coronary angiography, two-dimensional echocardiography and99mTc-tetrofosmin myocardial single photon emission computed tomography

  摘要：

  We studied the causative mechanism of ampulla (Takotsubo) cardiomyopathy. Methods: We examined 7 patients with ampulla cardiomyopathy by means of coronary angiography, two-dimensional echocardiography and Tc-99m-tetrofosmin myocardial SPECT at the time of emergency admission (acute phase), at 3 to 5 days after the attack (subacute phase) and at 1 month after the attack (chronic phase). The left ventricle was divided into 9 regions on two-dimensional echocardiograms and Tc-99m-tetrofosmin myocardial SPECT images, then the degree of abnormalities in each region was scored in four grades from normal (0) to severely abnormal (3). We injected nicorandil into the coronary arteries and determined the elevation in the ST segment before and after administration. Results: Coronary angiography did not show stenotic lesions in any patient. The acute, subacute and chronic phase myocardial perfusion scores on Tc-99m-tetrofosmin myocardial SPECT were 11.2 +/- 3.4, 2.7 +/- 2.3 and 0.4 +/- 0.5, respectively, and wall motion scores on echocardiograms were 13.0 +/- 3.6, 4.4 +/- 2.2 and 0.6 +/- 0.6, respectively, indicating improvement in all scores during the subacute phase (p < 0.01). The elevation in the ST segment (mm) on the electrocardiogram was improved from 8.3 +/- 2.7 to 4.9 +/- 1.9 after the administration of nicorandil (p < 0.05). Conclusion: These findings indicated that coronary microvascular spasm is one causative mechanism of ampulla cardiomyopathy.

  DOI：

  10.1007/bf02988242

文献信息

• [EN] NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS TRIFLUOROMÉTHYLEPROPANAMIDE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2016135070A1

  公开（公告）日：2016-09-01

  The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are as described herein, compositions including the compounds and methods of using the compounds.

  这项发明提供了具有通式（I）的新化合物，其中R1、R2、R3、R4、R5、R6和R7如本文所述，包括这些化合物的组合物以及使用这些化合物的方法。
• [EN] NEW DIFLUOROKETAMIDE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS DE DIFLUOROCÉTAMIDE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2016180751A1

  公开（公告）日：2016-11-17

  The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as described herein, compositions including the compounds and methods of using the compounds.

  该发明提供了具有一般化学式（I）的新化合物，其中R1、R2、R3、R4、R5、R6、R7、R8和R9如本文所述，包括这些化合物的组合物以及使用这些化合物的方法。
• Substituierte Phenoxyphenylpropionsäure-Derivate
  申请人：BAYER AG

  公开号：EP0166186A2

  公开（公告）日：1986-01-02

  Neue substituierte Phenoxyphenylpropionsäure-Derivate der Formel in welcher R' für Halogen, Trihalogenmethylsulfonyl oder Trihalogenmethyl steht, R2 und R3 unabhängig voneinander für Wasserstoff, Chlor oder Brom stehen, R4 und R5 unabhängig voneinander für Wasserstoff, Cyano, Thiocyano, Chlor oder Brom stehen und Z für Cyano oder für den Rest der Formel steht, in welcher Y für Hydroxy, Halogen, Alkoxy oder für den Rest der Formel steht, in welcher R6 und 11 unabhängig voneinander für Wasserstoff, Alkyl mit 1 bis 4 Kohlenstoffatomen sowie für gegebenenfalls einfach bis dreifach substituiertes Phenyl stehen, mehrere Verfahren zur Herstellung der neuen Stoffe und deren Verwendung als Herbizide.

  式中R'代表卤素、三卤甲基磺酰基或三卤甲基，R2和R3彼此独立地代表氢、氯或溴，R4和R5彼此独立地代表氢、氰基、硫氰基、氯或溴，Z代表氰基或式中Y代表羟基、卤素、烷氧基的其余部分或式中R6和11彼此独立地代表氢、具有1至4个碳原子的烷基和任选的一至三取代苯基的其余部分的新取代苯氧基苯丙酸衍生物，制备这些新物质的多种工艺及其作为除草剂的用途。
• Halogensubstituierte Phenoxyphenylpropionsäure-Derivate
  申请人：BAYER AG

  公开号：EP0313908A2

  公开（公告）日：1989-05-03

  Die Erfindung betrifft neue halogensubstituierte Phen­oxyphenylpropionsäure-Derivate der Formel wobei die Substituenten die in der Beschreibung ange­gebene Bedeutung haben, mehrere Verfahren und neue Zwischenprodukte zu ihrer Herstellung sowie ihre Verwendung als Herbizide und als Pflanzenwuchsregulatoren.

  本发明涉及新的卤代苯氧基苯丙酸衍生物，其式为 其中的取代基具有描述中给出的含义、制备它们的几种工艺和新中间体，以及它们作为除草剂和植物生长调节剂的用途。
• Microcapsules, a process for their preparation and their use
  申请人：CIBA-GEIGY AG

  公开号：EP0551796A2

  公开（公告）日：1993-07-21

  This invention relates to a process for encapsulation and particularly for the preparation of microcapsules having a capsule wall of a solid polymeric substance enclosing a water-immiscible material, which process comprises preparing a solution of a first reactive component required to form the capsule wall in the water-immiscible material, then dispersing the mixture in an aqueous medium containing a surfactant which is a salt of a partial ester of a styrene-maleic anhydride copolymer, to form an oil-in-water emulsion, and subsequently adding a second reactive component required to form the capsule wall which is complementary to the first one and reacts with it under the mixing conditions, whereby a solid polymeric wall is formed about the dispersed water-immiscible material. The resulting stable aqueous suspension of microcapsules can either be used directly or after dilution with water, or the microcapsules can be separated from the aqueous phase.

  本发明涉及一种封装工艺，特别是用于制备微胶囊的工艺，该微胶囊的囊壁由包覆水不混溶性材料的固体聚合物物质构成，该工艺包括制备在水不混溶性材料中形成囊壁所需的第一种活性成分的溶液、然后将混合物分散在含有表面活性剂的水介质中，表面活性剂是苯乙烯-马来酸酐共聚物部分酯的盐，以形成水包油型乳液，随后加入形成胶囊壁所需的第二种活性成分，第二种活性成分与第一种活性成分互补，并在混合条件下与第一种活性成分发生反应，从而在分散的不溶水材料周围形成固体聚合物壁。得到的稳定的微胶囊水悬浮液可以直接使用或用水稀释后使用，也可以将微胶囊从水相中分离出来。

表征谱图