5-{[5-(3,4-Dichlorophenyl)(2-furyl)]methylene}-2-thioxo-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-{[5-(3,4-Dichlorophenyl)(2-furyl)]methylene}-2-thioxo-1,3-thiazolidin-4-one
• 英文别名: (5E)-5-[[5-(3,4-dichlorophenyl)furan-2-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• 化学式: C₁₄H₇Cl₂NO₂S₂
• 分子量: 356.2
• InChiKey: VRRGUXZKRFEHEL-WUXMJOGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING VIRAL INFECTIONS AND ASSOCIATED DISEASES<br/>[FR] COMPOSES, COMPOSITIONS ET PROCEDES POUR TRAITER DES INFECTIONS VIRALES ET LES MALADIES QUI Y SONT LIEES
  申请人：VIROPHARMA INC

  公开号：WO2000010573A1

  公开（公告）日：2000-03-02

  Compounds, compositions and methods are provided for the treatment and prophylaxis of infections and associated diseases caused by viruses of the Flaviviridae family by administering certain rhodanine derivatives, and analogs thereof, tri- and tetracyclic rhodanine alkanoic acids and rhodanine benzoic acids being particularly effective.

  本发明提供了一种通过给予某些罗丹宁衍生物及其类似物、三环和四环罗丹宁烷基酸和罗丹宁苯甲酸来治疗和预防由黄病毒科病毒引起的感染和相关疾病的化合物、组合物和方法。其中，三环和四环罗丹宁烷基酸和罗丹宁苯甲酸具有特别有效的作用。
• Compounds, compositions and methods for treating or preventing viral infections and associated diseases
  申请人：——

  公开号：US20040198741A1

  公开（公告）日：2004-10-07

  Compounds, compositions and methods are provided for the treatment and prophylaxis of infections and associated diseases caused by viruses of the Flaviviridae family by administering certain rhodanine derivatives, and analogs thereof, tri- and tetracyclic rhodanine alkanoic acids and rhodanine benzoic acids being particularly effective.

  提供了用于治疗和预防由Flaviviridae家族病毒引起的感染和相关疾病的化合物、组合物和方法，通过给予某些硫代乙酰丙酮衍生物和其类似物、三环和四环硫代乙酰丙酮脂肪酸和硫代乙酰丙酮苯甲酸来特别有效地治疗。
• 2-thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-ACP reductase of type II fatty acid synthesis pathway and other cell growth pathways
  申请人：National Institute of Immunology

  公开号：EP1834642A2

  公开（公告）日：2007-09-19

  The current invention presents enoyl-ACP reductase, an enzyme of the type II fatty acid synthesis pathway as a target for treating human malarias and other infectious diseases. We also present in the current invention, 2-thioxothiazolidin-4-ones as antimicrobial and antimalarial agents. We provide 2-thioxothiazolidin-4-ones as antimicrobial and antimalarial agents either alone or in combination with other known antimicrobial and antimalarial agents with or without added adjuvants or diluents or carriers.

  本发明将 II 型脂肪酸合成途径中的一种酶--烯酰-ACP 还原酶作为治疗人类疟疾和其他传染性疾病的靶标。本发明还提出了作为抗菌剂和抗疟药物的 2-硫酮噻唑烷-4-酮。我们提供 2-硫酮噻唑烷-4-酮作为抗菌剂和抗疟药物，可以单独使用，也可以与其他已知的抗菌剂和抗疟药物结合使用，可以添加佐剂或稀释剂或载体，也可以不添加佐剂或稀释剂或载体。
• COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING VIRAL INFECTIONS AND ASSOCIATED DISEASES
  申请人：Viropharma Incorporated

  公开号：EP1128832A1

  公开（公告）日：2001-09-05
• EP1128832A4
  申请人：——

  公开号：EP1128832A4

  公开（公告）日：2003-03-05