(1S,3aS,4S,7aR)-7a-Methyl-5-oxo-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-octahydro-indene-1-carbonitrile | 210834-65-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: (1S,3aS,4S,7aR)-7a-Methyl-5-oxo-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-octahydro-indene-1-carbonitrile
• 英文别名: (1S,3aS,4S,7aR)-4-[2-[(8aR)-4,6,7,8-tetrahydro-1,3-benzodioxin-8a-yl]ethyl]-7a-methyl-5-oxo-3a-trimethylsilyloxy-1,2,3,4,6,7-hexahydroindene-1-carbonitrile
• CAS: 210834-65-4
• 化学式: C₂₄H₃₇NO₄Si
• 分子量: 431.648
• InChiKey: ZGYLYWBMNUQRTN-LVEKPIIGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.13
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  68.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (1S,3aS,4S,7aR)-7a-Methyl-5-oxo-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-octahydro-indene-1-carbonitrile 在 双(三甲基硅烷基)氨基钾 作用下， 以 四氢呋喃 为溶剂， 生成 Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-7a-methyl-6-methylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester
  参考文献：
  名称：

  Intramolecular Heck cyclization of α-sulfenyl enol triflates. Asymmetric synthesis of a pentacyclic cardenolide precursor having functionality at C-11

  摘要：

  A concise route to the core of complex cardenolides is described. The sequence features use of a sulfone to join enantioenriched A and D ring fragments and also control intramolecular aldolization to generate ring C and an intramolecular Heck cyclization of an alpha-sulfenyl enol triflate to form the steroid skeleton. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00860-0
• 作为产物：
  描述：

  (1S,7aR)-7a-Methyl-5-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-1-carbonitrile 在 正丁基锂 、 samarium diiodide 、 四丁基氟化铵 、 silica gel 、 双(三甲基硅烷基)氨基钾 、 臭氧 、 溶剂黄146 作用下， 以 四氢呋喃 、 氯仿 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 生成 (1S,3aS,4S,7aR)-7a-Methyl-5-oxo-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-octahydro-indene-1-carbonitrile
  参考文献：
  名称：

  Intramolecular Heck cyclization of α-sulfenyl enol triflates. Asymmetric synthesis of a pentacyclic cardenolide precursor having functionality at C-11

  摘要：

  A concise route to the core of complex cardenolides is described. The sequence features use of a sulfone to join enantioenriched A and D ring fragments and also control intramolecular aldolization to generate ring C and an intramolecular Heck cyclization of an alpha-sulfenyl enol triflate to form the steroid skeleton. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00860-0

文献信息

• Intramolecular Heck cyclization of α-sulfenyl enol triflates. Asymmetric synthesis of a pentacyclic cardenolide precursor having functionality at C-11
  作者：John Hynes、Larry E Overman、Talal Nasser、Paul V Rucker

  DOI：10.1016/s0040-4039(98)00860-0

  日期：1998.6

  A concise route to the core of complex cardenolides is described. The sequence features use of a sulfone to join enantioenriched A and D ring fragments and also control intramolecular aldolization to generate ring C and an intramolecular Heck cyclization of an alpha-sulfenyl enol triflate to form the steroid skeleton. (C) 1998 Elsevier Science Ltd. All rights reserved.