5-Iodo-2-[(3-methyl-4-nitrobenzoyl)amino]benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Iodo-2-[(3-methyl-4-nitrobenzoyl)amino]benzoic acid
• 化学式: C15H11IN2O5
• mdl: MFCD02032002
• 分子量: 426.16
• InChiKey: YUOTWEHZWGUTCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Inhibiting binding of influenza-virus PB2 subunit to RNA cap
  申请人：Sinoclone Ltd.

  公开号：US10792275B2

  公开（公告）日：2020-10-06

  The present invention is a method of inhibiting the replication of an influenza virus by using an antiviral compound to inhibit the binding of an influenza-virus PB2 subunit to an RNA cap. The antiviral compound may be 5-iodo-2-[(3-methyl-4-nitrobenzoyl)amino]benzoic acid; 3,3′-[(4-methylphenyl)methylene]bis(4-hydroxy-2H-chromen-2-one); or 7-(4-hydroxy-2-oxo-2H-chromen-3-yl)-6H,7H,8Hchromeno[3,4′:5,6]pyrano[3,2-c]chromene-6,8-dione. The aforementioned antiviral compounds have successfully inhibited the replication of influenza virus in vitro and in vivo in mouse models.

  本发明是一种通过使用抗病毒化合物抑制流感病毒PB2亚基与RNA帽结合来抑制流感病毒复制的方法。抗病毒化合物可以是 5-碘-2-[(3-甲基-4-硝基苯甲酰基)氨基]苯甲酸；3,3′-[(4-甲基苯基)亚甲基]双(4-羟基-2H-苯并吡喃-2-酮)；或 7-(4-羟基-2-氧代-2H-苯并吡喃-3-基)-6H,7H,8H-苯并吡喃[3,4′：5,6]pyrano[3,2-c]chromene-6,8-dione.上述抗病毒化合物成功地抑制了流感病毒在体外和小鼠模型体内的复制。
• Compound that Inhibits Binding of Influenza-Virus PB Subunit to RNA Cap
  申请人：Sinoclone Ltd.

  公开号：US20190142785A1

  公开（公告）日：2019-05-16

  The present invention provides a compound as shown in formula (I), formula (II), or formula (III), which can inhibit the binding of influenza virus PB2 protein to RNA cap and has an anti-influenza effect.