2-[2-(2-Sulfanylethyl)phenyl]benzaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-(2-Sulfanylethyl)phenyl]benzaldehyde
• 化学式: C₁₅H₁₄OS
• 分子量: 242.3
• InChiKey: UPBDMFBBBCVGAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  18.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• BILIRUBIN ANTIGEN, MONOCLONAL ANTIBODY THEREFOR, PROCESS FOR THEIR PREPARATION, AND THEIR USE
  申请人：KUKITA, Takeshi

  公开号：EP0307476A1

  公开（公告）日：1989-03-22

  A novel bilirubin antigen capable of functioning as an antigen which does not undergo decomposition in vivo. This antigen has a structure wherein a protein is bound to the methylene group of the outer vinyl group present in the outermost ring of bilirubin through a spacer or to at least one carboxyl group. A monoclonal antibody capable of recognizing the bilirubin antigen can be obtained from hybridoma cells prepared by cell fusion between antibody-yielding cells obtained by immunizing with the bilirubin antigen and tumor cells capable of division and growth in a culture medium. This monoclonal antibody can recognize bilirubins present in vivo without decomposing their structures, and hence it enables direct qualitative and analyses of bilirubins.

  一种新型胆红素抗原，能够作为一种在体内不分解的抗原发挥作用。这种抗原的结构是：蛋白质通过一个间隔物与胆红素最外层环中乙烯基外层的亚甲基或至少一个羧基结合。能够识别胆红素抗原的单克隆抗体可以从杂交瘤细胞中获得，杂交瘤细胞是通过免疫胆红素抗原获得的产生抗体的细胞与能够在培养基中分裂和生长的肿瘤细胞进行细胞融合而制备的。这种单克隆抗体可以识别体内存在的胆红素，而不会分解其结构，因此可以直接对胆红素进行定性和分析。