4-Iodophenyl butyrate | 29052-08-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 4-Iodophenyl butyrate
• 英文别名: (4-iodophenyl) butanoate
• CAS: 29052-08-2
• 化学式: C₁₀H₁₁IO₂
• 分子量: 290.1
• InChiKey: FHKUQGMEUYZHFO-UHFFFAOYSA-N

物化性质

• 沸点：
  302.7±25.0 °C(Predicted)
• 密度：
  1.592±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Microbubble complexes and methods of use
  申请人：General Electric Company

  公开号：US10004760B2

  公开（公告）日：2018-06-26

  The present invention relates to a microbubble complex comprising a microbubble having an outer shell comprising a mixture of native and denatured albumin encapsulating a perfluorocarbon gas, a therapeutic agent, a bifunctional linker having one end attached to the therapeutic agent and the other attached to a ligand and wherein the ligand is bound to the other shell of the microbubble through hydrophobic interactions. Also included are methods for delivering the aforementioned microbubble complex to a tissue target.

  本发明涉及一种微气泡复合物，该复合物包括一个微气泡，其外壳由包裹全氟碳气 体的原生白蛋白和变性白蛋白混合物、治疗剂、双功能连接体组成，双功能连接体的一 端连接治疗剂，另一端连接配体，其中配体通过疏水相互作用与微气泡的另一外壳结合。还包括将上述微泡复合物输送到组织靶点的方法。
• MICROBUBBLE COMPLEXES AND METHODS OF USE
  申请人：General Electric Company

  公开号：EP2758081A1

  公开（公告）日：2014-07-30
• COMPOSITIONS, DELIVERY SYSTEMS, AND METHODS USEFUL IN TUMOR THERAPY
  申请人：Indi Molecular, Inc.

  公开号：US20220211648A1

  公开（公告）日：2022-07-07

  Disclosed are compounds, compositions, systems, and methods useful for treating disease (such as cancer and tumors), or binding, detecting, and affecting compounds, compositions, cells, tissues, and organs, where the compounds, compositions, systems, and methods include or involve toxic compounds and where the toxic effect of the compounds, compositions, systems, and methods is reduced by providing a cleavage site to facilitate separation of the toxic component from other components of the compound, composition, or system. Preferably the system is a composition delivery system comprising or using a composition as disclosed herein. In some forms, the cleavage of the composition delivers a therapeutic agent and avoids organ damage by the composition.
• COMPOSITIONS, IMAGING, AND THERAPEUTIC METHODS TARGETING FOLATE RECEPTOR 1 (FOLR1)
  申请人：Indi Molecular, Inc.

  公开号：US20220229066A1

  公开（公告）日：2022-07-21

  The present application provides stable heterobiligands made up of peptide-based FOLR1 ligands and folate (the ligand of FOLR1) and methods of use of the heterobiligands as detection, imaging, diagnostic, and therapeutic agents. The application further provides methods of manufacturing FOLR1 heterobiligands, capture agents, and imaging agents.
• US6124109A
  申请人：——

  公开号：US6124109A

  公开（公告）日：2000-09-26