2,4,7-Trimethyl-fluorenon | 2928-33-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2,4,7-Trimethyl-fluorenon
• 英文别名: 2,4,7-Trimethyl-fluoren-9-on；2,4,7-Trimethylfluoren-9-one
• CAS: 2928-33-8
• 化学式: C₁₆H₁₄O
• 分子量: 222.287
• InChiKey: USZAAFMXMSGYBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  对甲基肉桂醛 在 potassium permanganate 、 硫酸 、 magnesium oxide 作用下， 生成 2,4,7-Trimethyl-fluorenon
  参考文献：
  名称：

  Godfroid,J.-J., Bulletin de la Societe Chimique de France, 1964, p. 2929 - 2943

  摘要：

  DOI：

文献信息

• PIPERIDINE/PIPERAZINE DERIVATIVES
  申请人：Janssen Pharmaceutica N.V.

  公开号：US20150087629A1

  公开（公告）日：2015-03-26

  The invention relates to a DGAT inhibitor of formula including any stereochemically isomeric form thereof, wherein A represents CH or N; the dotted line represents an optional bond in case A represents a carbon atom; X represents —O—C(═O)—; —C(═O)—C(═O)—; —NR x —C(═O)—; —Z—C(═O)—; —Z—NR x —C(═O)—; —C(═O)—Z—; —NR x —C(═O)—Z—; —C(═S)—; —NR x —C(═S)—; —Z—C(═S)—; —Z—NR x —C(═S)—; —C(═S)—Z—; —NR x —C(═S)—Z—; Z represents a bivalent radical selected from C 1-6 alkanediyl, C 2-6 alkenediyl or C 2-6 alkynediyl; wherein each of said C 1-6 alkanediyl, C 2-6 alkenediyl or C 2-6 alkynediyl may optionally be substituted; and wherein two hydrogen atoms attached to the same carbon atom in C 1-6 alkanediyl may optionally be replaced by C 1-6 alkanediyl; Y represents —C(═O)—NR x — or —NR x —C(═O)—; R 1 represents adamantanyl, C 3-6 cycloalkyl; aryl 1 or Het 1 ; R 2 represents C 3-6 cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxolyl, 2,3-dihydrobenzofuranyl or a 6-membered aromatic heterocycle containing 1 or 2 N atoms, wherein said C 3-6 cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxolyl or heterocycle may optionally be substituted; R 7 represents hydrogen, halo, C 1-4 alkyl, C 1-4 alkyl substituted with hydroxyl; provided that the following compounds are excluded; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine, as a DGAT inhibitor, of said compounds.
• US8946228B2
  申请人：——

  公开号：US8946228B2

  公开（公告）日：2015-02-03
• US9227935B2
  申请人：——

  公开号：US9227935B2

  公开（公告）日：2016-01-05
• US9724418B2
  申请人：——

  公开号：US9724418B2

  公开（公告）日：2017-08-08
• Godfroid,J.-J., Bulletin de la Societe Chimique de France, 1964, p. 2929 - 2943
  作者：Godfroid,J.-J.

  DOI：——

  日期：——