Isothialen | 270-63-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: Isothialen
• 英文别名: cyclopentathiapyran；Cyclopenta[c]thiopyran
• CAS: 270-63-3
• 化学式: C₈H₆S
• 分子量: 134.202
• InChiKey: WITCGPMUKHXQGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  β-(2-Brommethyl-cyclopentanyl-(1))-ethylbromid 在 sodium sulfide 、 palladium on activated charcoal 、 乙醇 作用下， 生成 Isothialen
  参考文献：
  名称：

  SYNTHESIS OF CYCLOPENTA[C]THIAPYRAN AND 2-PHENYL-2-PYRIDINE¹

  摘要：

  DOI：

  10.1021/ja01514a060

文献信息

• Vanilloid receptor ligands and their use in treatments
  申请人：——

  公开号：US20030195201A1

  公开（公告）日：2003-10-16

  Compounds having the general structure 1 and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

  具有一般结构1的化合物以及含有它们的组合物，用于治疗急性疼痛、炎症性和神经性疼痛、牙痛、普通头痛、偏头痛、丛集性头痛、混合性血管和非血管综合症、紧张性头痛、一般炎症、关节炎、风湿病、骨关节炎、炎症性肠病、炎症性眼病、炎症性或不稳定的膀胱病、银屑病、具有炎症成分的皮肤疾病、慢性炎症状况、炎症性疼痛及其相关的过度疼痛和异常疼痛、神经性疼痛及其相关的过度疼痛和异常疼痛、糖尿病性神经病疼痛、灼痛、交感神经维持的疼痛、去神经综合症、哮喘、上皮组织损伤或功能障碍、单纯疱疹、在呼吸、生殖泌尿、胃肠或血管区域的内脏运动障碍、伤口、烧伤、过敏性皮肤反应、瘙痒、白癜风、一般胃肠病、胃溃疡、十二指肠溃疡、腹泻、由坏死性剂引起的胃部病变、毛发生长、血管运动性或过敏性鼻炎、支气管障碍或膀胱障碍。
• HIGHLY EFFICIENT CARBAZOLE-BASED COMPOUND, AND ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING SAME
  申请人：Lee Jun Yeob

  公开号：US20130119367A1

  公开（公告）日：2013-05-16

  The present invention relates to a highly efficient carbazole-based compound and to an organic electroluminescence device including the same. According to the present invention, provided are a compound for an organic electroluminescence device and an organic electroluminescence device including the compound, in which a carbazole-based phosphine oxide compound, which is a compound intended for an organic electroluminescence device, is employed to overcome the problems of conventional compounds for organic electroluminescence devices, i.e. those of instable thermal stability and low efficiency, and particularly, the compound of the present invention exhibits superior efficiency in pure-blue phosphorescent devices.

  本发明涉及一种高效的基于咔唑的化合物，以及包含该化合物的有机电致发光器件。根据本发明，提供了一种用于有机电致发光器件的化合物和包含该化合物的有机电致发光器件，其中采用了一种基于咔唑的膦氧化物化合物，该化合物旨在用于有机电致发光器件，以克服传统有机电致发光器件化合物的问题，即热稳定性不稳定和低效率，特别是本发明的化合物在纯蓝色磷光器件中表现出卓越的效率。
• N-sulfonyl hydroxamic acid derivatives as inhibitors of cd23
  申请人：——

  公开号：US20030195191A1

  公开（公告）日：2003-10-16

  Compounds of formula (I): wherein R 1 is bicyclyl or heterobicyclyl, R 2 and R 3 are each independently hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl, (C1-6)alkylthio, (C2-6)alkenylthio, (C2-6)alkynylthio, aryloxy, arylthio, heterocyclyloxy, heterocyclythio, (C1-6)alkoxy, (C1-6)alkenyloxy, aryl(C1-6)alkoxy, aryl(C1-6)alkylthio, amino, mono- or di-(C1-6)alkylamino, acylamino, sulfonylamino, cycloalkyl, cycloalkenyl, carboxylic acid (C1-6) ester, hydroxy, halogen, carboxamide: CONR 8 R 9 where R 8 and R 9 are independently selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl and heterocyclyl and includes R 8 and R 9 as part of a heterocyclyl group, or R 2 and R 3 together form a cyclic alkyl or alkenyl; R 4 and R 5 are each independently aryl, heteroaryl, heterocyclyl, alkoxy, alkyl, hydroxy or optionally substituted amino; R 6 and R 7 are each hydrogen or together form a fused aryl ring; and m and n are each independently from 0 to 2; with the proviso that when n=1 neither R 4 nor R 5 is hydroxy, alkoxy or amino, are useful in the treatment and prophylaxis of conditions mediated by CD23 or TNF.

  化合物的式子(I): 其中R1是双环或杂双环，R2和R3分别是氢，烷基，烯基，炔基，芳基，杂芳基，杂环基，(C1-6)烷基硫，(C2-6)烯基硫，(C2-6)炔基硫，芳氧基，芳硫基，杂环氧基，杂环硫基，(C1-6)烷氧基，(C1-6)烯氧基，芳基(C1-6)烷氧基，芳基(C1-6)烷基硫，氨基，单烷基或双烷基(C1-6)氨基，酰胺基，磺酰胺基，环烷基，环烯基，羧酸(C1-6)酯，羟基，卤素，羧酰胺：CONR8R9，其中R8和R9分别选择自羟基，烷基，芳基，芳基烷基和杂环基的群体，并包括将R8和R9作为杂环基的一部分，或R2和R3一起形成环状烷基或烯基；R4和R5分别是芳基，杂芳基，杂环基，烷氧基，烷基，羟基或可选择取代氨基；R6和R7分别是氢或一起形成融合的芳环；m和n各自独立于0到2；但当n=1时，R4和R5均不是羟基，烷氧基或氨基，这些化合物可用于治疗和预防由CD23或TNF介导的疾病。
• Novel cd23 inhibitors
  申请人：——

  公开号：US20030134880A1

  公开（公告）日：2003-07-17

  Compounds of formula (I) wherein R is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl or heterocyclyl; R 1 is bicyclyl or heterobicyclyl; R 2 is aryl, heteroaryl, heterocyclyl, alkoxy, alkyl, hydroxy or optionally substituted amino and n is from 0 to 3; with the provisos than when n is 0 R 2 is alkyl or when n is from 1 to 3 R 2 is not alkyl, are useful in the treatment and prophylaxis of conditions mediated by CD23 or TNF.

  公式（I）的化合物，其中R是氢，烷基，烯基，炔基，芳基，杂芳基或杂环基; R1是双环芳基或杂双环芳基; R2是芳基，杂芳基，杂环基，烷氧基，烷基，羟基或可选取代的氨基，n为0至3; 假设当n为0时，R2是烷基，当n为1至3时，R2不是烷基。这些化合物在治疗和预防由CD23或TNF介导的疾病中有用。
• VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS
  申请人：Bo Yunxin Y.

  公开号：US20090264424A1

  公开（公告）日：2009-10-22

  Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

  具有一般结构和组成的化合物，用于治疗急性、炎症性和神经病性疼痛、牙痛、普通头痛、偏头痛、群集性头痛、混合型血管性和非血管性综合症、紧张性头痛、一般炎症、关节炎、风湿性疾病、骨关节炎、炎症性肠病、炎症性眼疾、炎症性或不稳定的膀胱疾病、牛皮癣、具有炎症成分的皮肤疾病、慢性炎症状况、炎症性疼痛和相关的高敏感性和触痛、神经病性疼痛和相关的高敏感性和触痛、糖尿病性神经病疼痛、烧伤后神经病疼痛、交感神经维持的疼痛、去神经化综合症、哮喘、上皮组织损伤或功能障碍、单纯疱疹、呼吸、泌尿、胃肠或血管区域的内脏运动障碍、创伤、烧伤、过敏性皮肤反应、瘙痒、白癜风、一般胃肠疾病、胃溃疡、十二指肠溃疡、腹泻、坏死性剂引起的胃病变、毛发生长、血管运动或过敏性鼻炎、支气管疾病或膀胱疾病。