Pyronin G | 17817-77-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: Pyronin G
• 英文别名: pyronine Y；pyronin Y；3,6-Bis(dimethylamino)xanthylium；[6-(dimethylamino)xanthen-3-ylidene]-dimethylazanium
• CAS: 17817-77-5
• 化学式: C₁₇H₁₉N₂O
• 分子量: 267.351
• InChiKey: MTENKDNBVMPHAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  15.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Pyronin G 在 1,2,3,4,5,6,7,8-八硫杂环辛烷 、 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 10.0h， 以50%的产率得到3,6-bis(dimethylamino)-9H-xanthene-9-thione
  参考文献：
  名称：

  荧光传感器，用于光气和神经气体模拟物之间的双通道区分

  摘要：

  快速有效地分析剧毒化学战剂（CWA）和相关化学物质的能力对于减轻意外恐怖袭击和工业事故对人类和公共安全的严重威胁至关重要。在这项研究中，我们设计了邻苯二胺-吡喃宁连接的染料，该染料能够在溶液或气相中通过光气和比色法区分光气和典型的神经药模拟物二乙基氯磷酸酯（DCP）。而且，这种染料已被用于构建一种便携式试剂盒，该试剂盒可用于歧视性地以及以一种简单而安全的方式实时监测该领域的DCP和光气。

  DOI：

  10.1002/anie.201601346
• 作为产物：
  描述：

  3,6-bis(dimethylamino)-9H-xanthen-9-one 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以34%的产率得到Pyronin G
  参考文献：
  名称：

  一种检测牙髓状态的次氯酸荧光探针

  摘要：

  本发明提供了一种检测牙髓状态的次氯酸荧光探针，具有式I所示结构。本发明的荧光探针对次氯酸有非常好的比率响应性，检测灵敏度高，可快速准确判断牙髓状态，为口腔临床操作中正确保存牙髓提供依据，具有极高的应用价值。

  公开号：

  CN114106031A

文献信息

• COMPOSITIONS AND METHODS FOR DETECTING NERVE AGENTS
  申请人：Corcoran Robert C.

  公开号：US20100130757A1

  公开（公告）日：2010-05-27

  The present invention provides methods and compositions for detecting, identifying and measuring the abundance of chemical nerve agents. Methods and compositions of the present invention are capable of providing selective detection of phosphorous based nerve agents, such as nerve agents that are esters of methyl phosphonic acid derivatives incorporating a moderately good leaving group at the phosphorus. Selectivity in the present invention is provided by a sensor composition having an alpha (α) effect nucleophile group that undergoes specific nucleophilic substitution and rearrangement reactions with phosphorus based nerve agents having a tetrahederal phosphorous bound to oxygen. The present invention includes embodiments employing a sensor composition further comprising a reporter group covalently linked to the alpha effect nucleophile group allowing rapid optical readout of nerve agent detection events, including direct visual readout and optical readout via spectroscopic analysis.

  本发明提供了用于检测、识别和测量化学神经毒剂丰度的方法和组合物。本发明的方法和组合物能够选择性地检测基于磷的神经毒剂，例如酯化了在磷上具有中等良好离去基团的甲基膦酸衍生物的神经毒剂。本发明中的选择性是通过具有α效应亲核基团的传感器组合物提供的，该亲核基团与磷基神经毒剂发生特定的亲核取代和重排反应，其中磷与氧结合形成四面体磷。本发明包括采用传感器组合物的实施例，该传感器组合物进一步包括与α效应亲核基团共价连接的报告基团，允许对神经毒剂检测事件进行快速光学读数，包括直接视觉读数和通过光谱分析的光学读数。
• Reagents and methods for direct labeling of nucleotides
  申请人：Naleway John J.

  公开号：US20130150254A1

  公开（公告）日：2013-06-13

  The present invention provides systems and methods for production of activatable diazo-derivatives for use in labeling nucleotides. Labeling nucleotides is accomplished by contacting a stable hydrazide derivative of a detectable moiety with an activating polymer reagent which is used to directly label the nucleotide sample. Labeling occurs on the phosphate backbone of the nucleotide which does not perturb hybridization of the labeled nucleotide with its anti-sense strand. Since the method involves direct labeling, all types of nucleotides can be labeled without prior amplification or alteration.

  本发明提供了用于生产可激活重氮衍生物以用于标记核苷酸的系统和方法。通过将可检测基团的稳定的肼酰肼衍生物与用于直接标记核苷酸样品的活化聚合物试剂接触来完成核苷酸的标记。标记发生在核苷酸的磷酸骨架上，不会干扰标记核苷酸与其反义链的杂交。由于该方法涉及直接标记，所有类型的核苷酸都可以在不经过扩增或改变的情况下进行标记。
• COMPOUND AND COMPOSITION FOR DETECTING PHOSGENE AND DIETHYL CHLOROPHOSPHATE
  申请人：EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION

  公开号：US20170240557A1

  公开（公告）日：2017-08-24

  The present invention relates to a compound for detecting phosgene and DCP (diethyl chlorophosphate) and a composition for detecting phosgene and DCP (diethyl chlorophosphate) comprising the said compound. More precisely, the compound for detecting phosgene and DCP of the present invention can selectively detect phosgene and DCP either in the liquid phase of gas phase by detecting the changes of fluorescence and color development very quickly within a few seconds with nM sensitivity. Therefore, the compound can also be effectively used as an ingredient for the composition and kit for the detection of one or more materials selected from the group consisting of phosgene and DCP.

  本发明涉及一种用于检测光气和DCP（二乙基氯磷酸酯）的化合物，以及包含该化合物的用于检测光气和DCP（二乙基氯磷酸酯）的组合物。更准确地说，本发明的用于检测光气和DCP的化合物可以通过在几秒钟内非常快速地检测荧光和颜色变化来选择性地检测光气和DCP，无论是在液相还是气相中，灵敏度为纳摩尔级。因此，该化合物还可以有效地用作用于检测光气和DCP的组合物和试剂盒的成分，用于检测来自包括光气和DCP在内的一组材料中的一个或多个材料。
• Mitochondrially targeted antioxidants
  申请人：Murphy P. Michael

  公开号：US20050227957A1

  公开（公告）日：2005-10-13

  The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.

  这项发明提供了线粒体靶向抗氧化化合物，包括一个与谷胱甘肽过氧化物酶类似物共价偶联的疏水阳离子基团。这些化合物可用于治疗需要减少氧化应激的患者。
• FLUOROURETHANE AS AN ADDITIVE IN A PHOTOPOLYMER FORMULATION
  申请人：Rölle Thomas

  公开号：US20120231376A1

  公开（公告）日：2012-09-13

  The invention relates to a photopolymer formulation comprising matrix polymers, writing monomers, and photoinitiators, to the use of the photopolymer formulation for producing optical elements, in particular for producing holographic elements and images, to a method for illuminating holographic media made of the photopolymer formulation, and to special fluorourethanes.

  本发明涉及一种光聚合物配方，包括基质聚合物、写入单体和光引发剂，用于生产光学元件，特别是用于生产全息元件和图像，以及用于照明由该光聚合物配方制成的全息介质的方法，还涉及特殊的氟聚氨酯。