9-(1-(2-chlorophenyl)-2-nitroethyl)anthracen-10(9H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 9-(1-(2-chlorophenyl)-2-nitroethyl)anthracen-10(9H)-one
• 英文别名: 10-[1-(2-chlorophenyl)-2-nitroethyl]-10H-anthracen-9-one
• 化学式: C₂₂H₁₆ClNO₃
• 分子量: 377.827
• InChiKey: FGLURAFAQQYYJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  蒽酮 、 1-chloro-2-(2-nitrovinyl)benzene 以 水 为溶剂， 反应 18.0h， 以83%的产率得到9-(1-(2-chlorophenyl)-2-nitroethyl)anthracen-10(9H)-one
  参考文献：
  名称：

  Michael Addition Reaction of Anthrone to Nitroolefins in Water

  摘要：

  Michael addition reaction of anthrone to nitroolefins is described in water without using any catalyst to prepare 9-(2-nitro-1-arylethyl)anthracene-10(9H)-ones. This method is green and efficient and gives good yields of products. The solvent effect is also investigated.

  DOI：

  10.1080/00397911.2011.608479

文献信息

• Enantioselective Michael addition of anthrone to nitroalkenes catalyzed by bifunctional thiourea-tertiary amines
  作者：Yu-Hua Liao、Hui Zhang、Zhi-Jun Wu、Lin-Feng Cun、Xiao-Mei Zhang、Wei-Cheng Yuan

  DOI：10.1016/j.tetasy.2009.09.023

  日期：2009.10

  A highly bifunctional thiourea-tertiary amine-catalyzed enantioselective Michael addition reaction of anthrone to a wide variety of nitroalkenes has been developed, and the corresponding adducts were obtained smoothly in high yields (up to 97%) and good enantioselectivities (up to 94% ee). Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
• Michael Addition Reaction of Anthrone to Nitroolefins in Water
  作者：Azim Ziyaei Halimehjani、Nafiseh Karimi、Mohammad R. Saidi

  DOI：10.1080/00397911.2011.608479

  日期：2013.1.1

  Michael addition reaction of anthrone to nitroolefins is described in water without using any catalyst to prepare 9-(2-nitro-1-arylethyl)anthracene-10(9H)-ones. This method is green and efficient and gives good yields of products. The solvent effect is also investigated.