3-chloro-1,4-bis(4-methoxyphenyl)azetidin-2-one | 1251938-85-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 3-chloro-1,4-bis(4-methoxyphenyl)azetidin-2-one
• CAS: 1251938-85-8
• 化学式: C₁₇H₁₆ClNO₃
• 分子量: 317.772
• InChiKey: MAKSLGJOEWEGAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(4-甲氧基亚苄基)-4-甲氧基苯胺 、 氯乙酸 在 2-氟-1-甲基吡啶翁对甲苯磺酸盐 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以59%的产率得到3-chloro-1,4-bis(4-methoxyphenyl)azetidin-2-one
  参考文献：
  名称：

  A convenient synthesis of 2-azetidinones via 2-fluoro-1-methylpyridinium p-toluenesulfonate

  摘要：

  The application and versatility of 2-fluoro-1-methylpyridinium p-toluenesulfonate as acid activator in the synthesis of several beta-lactams under mild reaction conditions by use of ketene-imine cycloaddition reactions has been investigated. The effects of solvents, molar ratio of reagents, and temperature were considered. The method was also used for preparation of beta-lactams substituted in position 3 by electron-withdrawing groups. The products are obtained in good to excellent yields..

  DOI：

  10.1007/s00706-012-0918-y

文献信息

• A convenient synthesis of 2-azetidinones via 2-fluoro-1-methylpyridinium p-toluenesulfonate
  作者：Maaroof Zarei

  DOI：10.1007/s00706-012-0918-y

  日期：2013.7

  The application and versatility of 2-fluoro-1-methylpyridinium p-toluenesulfonate as acid activator in the synthesis of several beta-lactams under mild reaction conditions by use of ketene-imine cycloaddition reactions has been investigated. The effects of solvents, molar ratio of reagents, and temperature were considered. The method was also used for preparation of beta-lactams substituted in position 3 by electron-withdrawing groups. The products are obtained in good to excellent yields..