N²-Phenoxyacetyl-2-aminopurine | 144782-24-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: N²-Phenoxyacetyl-2-aminopurine
• 英文别名: 2-phenoxy-N-(7H-purin-2-yl)acetamide
• CAS: 144782-24-1
• 化学式: C₁₃H₁₁N₅O₂
• 分子量: 269.263
• InChiKey: BJMBAEOLFPGOTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  92.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N²-Phenoxyacetyl-2-aminopurine 、 2,2,2-Trichloro-acetimidic acid (2S,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl ester 在 三氟甲磺酸三甲基硅酯 作用下， 以 1,2-二氯乙烷 为溶剂， 以77%的产率得到
  参考文献：
  名称：

  Efficient synthesis of 2′-O-alkyl ribonucleosides using trichloroacetimidate d-ribofuranosides as ribosyl donors

  摘要：

  Trichloroacetimidate-2-O-alkyl-3, 5-O-TIPS-beta-D-ribofuranoside glycosylates silylated nucleobases in a fast high-yielding and stereoselective reaction promoted by trimethylsilyl trifluoromethanesulfonate. This method has been applied to the synthesis of 2'-O-alkyl ribonucleosides further transformed to building blocks ready for oligo(2'-O-alkyl)ribonucleotide construction.

  DOI：

  10.1016/s0040-4039(00)75987-9

文献信息

• Chemical synthesis of methoxy nucleosides
  申请人：Ribozyme Pharmaceuticals, Inc.

  公开号：US20030204078A1

  公开（公告）日：2003-10-30

  Process for chemical synthesis of methoxy nucleosides.

  甲氧基核苷化合物的化学合成过程。
• Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
  申请人：RIBOZYME PHARMACEUTICALS, INC.

  公开号：EP1108724A2

  公开（公告）日：2001-06-20

  This invention relates to chemical synthesis of 2'-O-methyl, 3'-O-methyl and 5'-O-methyl nucleosides, incorporation of novel chemical modifications in enzymatic nucleic acid molecules and improved methods for the synthesis of enzymatic nucleic acid molecules.

  本发明涉及 2'-O-甲基、3'-O-甲基和 5'-O-甲基核苷的化学合成、在酶核酸分子中加入新型化学修饰以及改进酶核酸分子的合成方法。
• PhenylsulfenylD-ribofuranosides as efficient ribosyl donors: Application to the synthesis of [1′,-13C]-(deoxy)nucleosides
  作者：Luc Chanteloup、Jean-Marie Beau

  DOI：10.1016/s0040-4039(00)79089-7

  日期：1992.9

  Readily available phenylsulfenyl 2,3,5-tri-O-benzoyl-beta-D-ribofuranoside glycosylates silylated nucleobases in a fast, high-yielding and stereoselective reaction promoted by trimethylsilyl trifluoromethanesulfonate. The method has been applied to the synthesis of [1'-C-13] labelled nucleosides further transformed to building blocks ready for oligodeoxynucleotide construction.
• EP0886641A2
  申请人：——

  公开号：EP0886641A2

  公开（公告）日：1998-12-30
• US6972330B2
  申请人：——

  公开号：US6972330B2

  公开（公告）日：2005-12-06