Propan-2-yl 2-{[(2-ethoxyphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Propan-2-yl 2-{[(2-ethoxyphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
• 英文别名: propan-2-yl 2-[(2-ethoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
• 化学式: C₂₁H₂₅NO₄S
• mdl: MFCD01327813
• 分子量: 387.5
• InChiKey: IQKPOSDNRXYXNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  92.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Small molecule efflux pump inhibitors
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US10471028B2

  公开（公告）日：2019-11-12

  Small molecule efflux pump inhibitors are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the small molecule efflux pump inhibitors to restore the antibiotic susceptibility of microbes.

  本文提供了小分子外排泵抑制剂及其用于治疗感染的方法。本文还提供了使用小分子外排泵抑制剂恢复微生物抗生素敏感性的方法。
• SMALL MOLECULE EFFLUX PUMP INHIBITORS
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20170100414A1

  公开（公告）日：2017-04-13

  Small molecule efflux pump inhibitors are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the small molecule efflux pump inhibitors to restore the antibiotic susceptibility of microbes.