2,6-dimethyl-N-methylidyneanilinium

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-dimethyl-N-methylidyneanilinium
• 英文别名: (2,6-dimethylphenyl)-methylidyneazanium
• 化学式: C9H10N+
• 分子量: 132.18
• InChiKey: PPICWFDZZGVESF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  4.4
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• SPIRO-gamma-LACTAMSAND, AND PREPARATION METHOD AND USE THEREOF
  申请人：Chongqing University of Arts and Sciences

  公开号：US20220009942A1

  公开（公告）日：2022-01-13

  Disclosed is a compound of Formula I or a pharmaceutically acceptable salt thereof, preparation methods thereof, pharmaceutical composition comprising the same, and use thereof in the treatment of diseases such as pancreatic cancer.

  公开的是I式化合物或其药用可接受盐，其制备方法，包括该化合物的药物组合物，以及在治疗胰腺癌等疾病中的用途。
• ALPHA-AMINOAMIDINE POLYMERS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20140322309A1

  公开（公告）日：2014-10-30

  α-Aminoamidine polymers and methods of preparing a-aminoamidine polymers by reacting by reacting one or more amines with one or more isocyanides and one or more aldehydes are described. Methods of preparing a-aminoamidine polymers from commercially available starting materials are also provided, wherein the starting materials are racemic or stereochemically pure. a-Aminoamidine polymers or salt forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems and for other purposes as well such as, for example, coatings, additives, excipients, plastics, and materials, etc. Given the amino moiety of these α-aminoamidine polymers, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive α-aminoamidine polymers and polynucleotides can be prepared. The inventive α-aminoamidine polymers may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
• US9872911B2
  申请人：——

  公开号：US9872911B2

  公开（公告）日：2018-01-23
• [EN] MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE<br/>[FR] MODULATION DE L'ACTIVITE PHOSPHORYL TRANSFERASE DE LA GLUTAMINE SYNTHETASE
  申请人：CSIR

  公开号：WO2007105023A1

  公开（公告）日：2007-09-20

  [EN] Methods of screening and designing compounds as inhibitors of glutamine synthetase, including adenylylated glutamine synthetase, are provided herein. Compounds and compositions useful for the treatment, prevention, and/or amelioration of bacterial infections, including Mycobacterium tuberculosis, are also provided.
  [FR] La présente invention concerne des procédés de criblage et de conception de composés en tant qu'inhibiteurs de la glutamine synthétase, y compris de la glutamine synthétase adénylylée. L'invention concerne de plus des composés et des compositions utiles pour le traitement, la prévention et/ou l'amélioration d'infections bactériennes, y compris par Mycobacterium tuberculosis.
• [EN] ALPHA-AMINOAMIDINE POLYMERS AND USES THEREOF<br/>[FR] POLYMÈRES D'ALPHA-AMINOAMIDINE ET LEURS UTILISATIONS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2013090861A1

  公开（公告）日：2013-06-20

  α-Aminoamidine polymers and methods of preparing a-aminoamidine polymers by reacting by reacting one or more amines with one or more isocyanides and one or more aldehydes are described. Methods of preparing a-aminoamidine polymers from commercially available starting materials are also provided, wherein the starting materials are racemic or stereochemically pure. a-Aminoamidine polymers or salt forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems and for other purposes as well such as, for example, coatings, additives, excipients, plastics, and materials, etc. Given the amino moiety of these α-aminoamidine polymers, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive α-aminoamidine polymers and polynucleotides can be prepared. The inventive α-aminoamidine polymers may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.