苯基乙酰基烯硫醇 | 62472-99-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苯基乙酰基烯硫醇
• 英文名称: 2-Phenylethynethiol
• CAS: 62472-99-5
• 化学式: C₈H₆S
• 分子量: 134.2
• InChiKey: NIYLSIICDGDKEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2930909090

文献信息

• Coating liquid for producing insulating film having low dielectric constant
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20030130391A1

  公开（公告）日：2003-07-10

  Coating liquid for producing insulating film having low dielectric constant is provided. It was achieved by coating liquid for producing insulating film having low dielectric constant comprising a thermosetting resin having carbon-carbon unsaturated bond, an organic solvent, and less than two molecular equivalents of water to the carbon-carbon unsaturated bond.

  提供了用于生产低介电常数绝缘膜的涂布液。它是通过生产低介电常数绝缘膜的涂布液实现的，涂布液由具有碳-碳不饱和键的热固性树脂、有机溶剂和少于碳-碳不饱和键两个分子当量的水组成。
• BLOCK POLYMER, COMPOSITE OF METAL AND BLOCK POLYMER, AND DEVICE
  申请人：Sone Takeyuki

  公开号：US20090061255A1

  公开（公告）日：2009-03-05

  A composite having a metal substance bonded to a block polymer. The composite is capable of electric bonding via the metallic substance. A device in which a pair of electrodes are connected via a polymer chain of the block polymer. The block polymer has in at least a part thereof a block structure of a repeating unit that has in a side chain thereof an organic functional group for bonding to at least one of the metallic entities. The polymer main chain of the block structure has a helical shape. In the composite of a metal and the block polymer, a part of the block structure of the block polymer is bonded to the metal species. In the device having the block polymer and an electrode composed of the metallic substance, a part of the block structure of the block polymer is bonded to the metallic substance.
• ALANINE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE
  申请人：Arvinas, Inc.

  公开号：US20170037004A1

  公开（公告）日：2017-02-09

  The description relates to Inhibitors of Apoptosis Proteins (IAPs) binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the IAP E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.
• LINKED DIARYL COMPOUNDS WITH ANTICANCER PROPERTIES AND METHODS OF USING THE SAME
  申请人：University of Maryland, College Park

  公开号：US20170174620A1

  公开（公告）日：2017-06-22

  Provided are compositions comprising linked diaryl compounds that possess anticancer properties. Methods of use are also disclosed herein. The method comprises administering an effective amount of a compound described herein to an individual in need thereof.
• MODULATORS OF BTK PROTEOLYSIS AND METHODS OF USE
  申请人：Yale University

  公开号：US20200121684A1

  公开（公告）日：2020-04-23

  The present disclosure relates to bifunctional compounds, which find utility as modulators of Burton's Tyrosine Kinase (BTK). In particular, the present disclosure is directed to bifunctional compounds. One end of a bifunctional compound includes a Von Hippel-Lindau, Cereblon, Inhibitors of Apotosis Proteins, or Mouse Double-Minute Homolog 2 ligand that binds to the respective E3 ubiquitin ligase. The other end of a bifunctional compound includes a moiety that binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. Diseases or disorders that result from aggregation, accumulation, and/or overactivation of the target protein can be treated or prevented with compounds and compositions of the present disclosure.