15H-indeno[1',2':5,6]pyrazino[2,3-b]phenazin-15-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 15H-indeno[1',2':5,6]pyrazino[2,3-b]phenazin-15-one
• 英文别名: 4,11,15,25-tetrazahexacyclo[12.11.0.03,12.05,10.016,24.017,22]pentacosa-1,3,5,7,9,11,13,15,17,19,21,24-dodecaen-23-one
• 化学式: C₂₁H₁₀N₄O
• mdl: MFCD00370814
• 分子量: 334.337
• InChiKey: ZOMBMWSXUADTGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,3-二氨基吩嗪 、 水合茚三酮 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以43%的产率得到15H-indeno[1',2':5,6]pyrazino[2,3-b]phenazin-15-one
  参考文献：
  名称：

  On the Synthesis of Pyrazino[2,3-b]phenazine and 1H-Imidazo[4,5-b]phenazine Derivatives

  摘要：

  Several pyrazino[2,3-D]phenazine derivatives were prepared by the reaction of 2,3-diaminophenazine with different 1,2-diketones. Nucleophilic substitution of 2,3-dibromomethyl-pyrazino[2,3-b]phenazine with propanol, morpholine, and potassium thiocyanate gave 2,3-bis(propoxymethyl)-pyrazino[2,3-b]phenazine 2,3-bis-(4-morpholinylmethyl)-pyrazino[2,3-b]phenazine, and 2,3-bis-(cyanosulfanylmethyl)-pyrazino[2,3-b]phenazine. 2-Aryl-1H-imidazo[4,5-b]phenazine derivatives were synthesized by a one-pot reaction of 1,3-diaminophenazine with different aromatic aldehydes or acids. Reaction of 2,3-diaminophenazine with acetic anhydride and formic acid afforded 1H-imidazo[4,5-b]phenazine and 2-methyl-1H-imidazo[4,5-b]phenazine. Chemical and spectroscopic evidences for the product structures of the new compounds are presented.

  DOI：

  10.1007/pl00010183