1-phenyl-2-((pyridin-2'-yl)methylamino)-ethanol | 64258-57-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-phenyl-2-((pyridin-2'-yl)methylamino)-ethanol
• 英文别名: 1-Phenyl-2-[(pyridin-2-ylmethyl)amino]ethanol；1-phenyl-2-(pyridin-2-ylmethylamino)ethanol
• CAS: 64258-57-7
• 化学式: C₁₄H₁₆N₂O
• mdl: MFCD05269382
• 分子量: 228.294
• InChiKey: GGLNJIYDKMKAMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.214
• 拓扑面积：
  45.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-phenyl-2-(pyridin-2-ylmethylamino)ethanone;dihydrochloride 、 硼氢化钠 以76%的产率得到
  参考文献：
  名称：

  BINIECKI S.; LEPACH M., ROCZ. CHEM. , 1977, 51, NO 3, 571-575

  摘要：

  DOI：

文献信息

• Synthesis of β-amino alcohols using MgO as a new catalyst under solvent-free conditions
  作者：Mona Hosseini-Sarvari

  DOI：10.1139/v07-135

  日期：2008.1.1

  MgO catalyzed efficiently the ring opening of epoxides with a range of aromatic and aliphatic amines to produce β-substituted alcohols in high yields under solvent-free conditions. Exclusive trans stereoselectivity is observed for cyclic epoxide.Key words: MgO, β-amino alcohols, solvent-free, epoxide, amine.

  在无溶剂条件下，氧化镁可高效催化环氧化物与一系列芳香族和脂肪族胺的开环反应，从而高产率地生成β-取代醇。环氧化物具有独特的反式立体选择性：氧化镁、β-氨基醇、无溶剂、环氧化物、胺。
• Solvent-Free Al(OTf)₃-Catalyzed Aminolysis of 1,2-Epoxides by 2-Picolylamine:  A Key Step in the Synthesis of Ionic Liquids
  作者：Francesco Fringuelli、Ferdinando Pizzo、Simone Tortoioli、Luigi Vaccaro

  DOI：10.1021/jo049335f

  日期：2004.10.1

  beta-Amino alcohols N-2'-pyridylmethyl substituted 3 have been prepared in excellent yields under mild conditions by the first Lewis acid-catalyzed aminolysis of 1,2-epoxides 1 with the bihaptic amine 2-picolylamine (2) with use of 5 mol % of Al(OTf)3 under solvent-free conditions. As a representative of a new class of ionic liquids, cis-5[(4'-methylphenyl)sulfonyl]-1,2,3,4,4a,5,6,11a-octahydropyrido[1,2-alpha]quinoxalin-11-ium methanesulfonate (6) and its chloride derivative 7 have been synthesized under environmentally friendly conditions by the one-pot aminolysis of cyclohexene oxide (1a) with 2 and intramolecular cyclization of the resulting 2-[(pyridin-2'-yl)methylamino]cyclohexanol (3a).