代谢
奎奴普丁和达福普丁转化为几个主要活性代谢物:奎奴普丁有2个结合型代谢物(与谷胱甘肽和半胱氨酸结合)和达福普丁有1个非结合型代谢物(通过水解形成),这些代谢物与互补的母药协同作用。这种转化是通过非酶促反应在体外发生的,独立于细胞色素P-450(CYP)和谷胱甘肽转移酶酶。
Quinupristin and dalfopristin are converted to several major active metabolites: 2 conjugated (with glutathione and cysteine) metabolites for quinupristin and one nonconjugated (formed by hydrolysis) metabolite for dalfopristin, which also act synergistically with the complementary parent drug. This conversion occurs in vitro by nonenzymatic reactions independent of cytochrome P-450 (CYP) and glutathione transferase enzymes.
来源:Hazardous Substances Data Bank (HSDB)