5-(1H-indol-3-ylmethyl)-3-[(4-methylphenyl)methyl]imidazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-(1H-indol-3-ylmethyl)-3-[(4-methylphenyl)methyl]imidazolidine-2,4-dione
• 化学式: C₂₀H₁₉N₃O₂
• 分子量: 333.4
• InChiKey: XCJDWXKWELWSFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  65.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• SMALL MOLECULE INHIBITORS OF NECROPTOSIS
  申请人：Yuan Junying

  公开号：US20120122889A1

  公开（公告）日：2012-05-17

  The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I)-(VIII) and by Compounds (I)-(I), (13)-(26), (27)-(33), (48)-(57), and (58)-(70). These necrostatins are shown to inhibit TNF-α induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring necrostatins. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.
• Necroptosis Inhibitors and Methods of Use Therefor
  申请人：Yuan Junying

  公开号：US20140066466A1

  公开（公告）日：2014-03-06

  Described herein are compositions that inhibit the production of TNFα downstream of CD40 activation. As such, also described are various methods of using compositions exhibiting this activity for the treatment or prevention of inflammatory diseases associated with TNFα production or CD40 activation.
• US9586880B2
  申请人：——

  公开号：US9586880B2

  公开（公告）日：2017-03-07
• US9643977B2
  申请人：——

  公开号：US9643977B2

  公开（公告）日：2017-05-09