1-phenyl-2,5-cis-dimethylpyrrolidine | 81480-60-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-phenyl-2,5-cis-dimethylpyrrolidine
• 英文别名: (2R,5S)-2,5-dimethyl-1-phenylpyrrolidine
• CAS: 81480-60-6
• 化学式: C₁₂H₁₇N
• 分子量: 175.274
• InChiKey: LFUBSXXNGAHHLS-PHIMTYICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,5-己二酮 、 苯胺 以99%的产率得到
  参考文献：
  名称：

  Boga Carla, Manescalchi Francesco, Savoia Diego, Tetrahedron, 50 (1994) N 16, S 4709-4722

  摘要：

  DOI：

文献信息

• Diastereoselective synthesis of 2,5-dimethylpyrrolidines and 2,6-dimethylpiperidines by reductive amination of 2,5-hexanedione and 2,6-heptanedione with hydride reagents
  作者：Carla Boga、Francesco Manescalchi、Diego Savoia

  DOI：10.1016/s0040-4020(01)85010-9

  日期：1994.4

  The reductive amination of 2,5-hexanedione and 2,6-heptanedione with ammonia and primary amines in the presence of hydride reagents afforded 2,5-dimethylpyrrolidines and 2,6-dimethylpiperidines with variable diastereoselectivity, as the cis/trans ratio was affected by the size of the ring formed and the steric and electronic properties of the nitrogen substituent. Increasing the bulkiness of the nitrogen substituent, the cis pyrrolidines and the bans-piperidines were obtained with enhanced selectivity.
• Barluenga, J.; Najera, C.; Yus, M., Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 1297 - 1299
  作者：Barluenga, J.、Najera, C.、Yus, M.

  DOI：——

  日期：——
• Boga Carla, Manescalchi Francesco, Savoia Diego, Tetrahedron, 50 (1994) N 16, S 4709-4722
  作者：Boga Carla, Manescalchi Francesco, Savoia Diego

  DOI：——

  日期：——
• 10.3390/molecules29112565
  作者：Liao, Jianhua、Tong, Jinghui、Liu, Liang、Ouyang, Lu、Luo, Renshi

  DOI：10.3390/molecules29112565

  日期：——